Abstract:
:Myasthenia gravis (MG) is caused by autoantibodies to the acetylcholine receptor (AChR). Experiments with fetal (alpha(2)betagammadelta) and adult (alpha(2)betaepsilondelta) AChR and with recombinant subunit dimers showed that some monoclonal antibodies (mAbs) against the main immunogenic region (MIR), located on the alpha-subunit of the AChR, bind better to fetal AChR and to alphagamma subunit dimer than to adult AChR and alphaepsilon dimer and equally to both alphabeta and alphadelta. However, other anti-MIR mAbs prefer adult AChR and alphaepsilon dimer, bind well to alphabeta but weakly to alphadelta. These results suggest that the MIR conformation is affected by the neighboring gamma/epsilon- and delta-subunits and may contribute to understanding the antibody specificities in MG.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fostieri E,Beeson D,Tzartos SJdoi
10.1016/s0014-5793(00)01980-3keywords:
subject
Has Abstractpub_date
2000-09-15 00:00:00pages
127-30issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01980-3journal_volume
481pub_type
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