Abstract:
:Epiregulin (EPR), a novel member of epidermal growth factor (EGF) family, is a ligand for ErbB-1 and ErbB-4 receptors. The binding affinity of EPR for the receptors is lower than those of other EGF-family ligands. The solution structure of EPR was determined using two-dimensional nuclear magnetic resonance spectroscopy. The secondary structure in the C-terminal domain of EPR is different from other EGF-family ligands because of the lack of hydrogen bonds. The structural difference in the C-terminal domain may provide an explanation for the reduced binding affinity of EPR to the ErbB receptors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sato K,Nakamura T,Mizuguchi M,Miura K,Tada M,Aizawa T,Gomi T,Miyamoto K,Kawano Kdoi
10.1016/s0014-5793(03)01005-6keywords:
subject
Has Abstractpub_date
2003-10-23 00:00:00pages
232-8issue
3eissn
0014-5793issn
1873-3468pii
S0014579303010056journal_volume
553pub_type
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