Abstract:
:We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Canario AV,Rotllant J,Fuentes J,Guerreiro PM,Rita Teodósio H,Power DM,Clark MSdoi
10.1016/j.febslet.2005.12.023keywords:
subject
Has Abstractpub_date
2006-01-09 00:00:00pages
291-9issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01484-5journal_volume
580pub_type
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