Abstract:
:Neurotrophins support neuronal survival, development, and plasticity through processes requiring gene expression. We studied how vgf target gene transcription is mediated by a critical promoter region containing E-box, CCAAT and cAMP response element (CRE) sites. The p300 acetylase was present in two distinct protein complexes bound to this region. One complex, containing HEB (ubiquitous basic helix-loop-helix (bHLH)), bound the promoter in non-neuronal cells and was involved in repressing vgf expression. Neurotrophin-dependent transcription was mediated by the second complex, specific for neuronal cells, which included CRE binding protein and MASH1 (neuro-specific bHLH), bound the CCAAT motif, and was target of neurotrophin signalling. The interaction, mediated by p300, of different transcription factors may add specificity to the neurotrophin response.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mandolesi G,Gargano S,Pennuto M,Illi B,Molfetta R,Soucek L,Mosca L,Levi A,Jucker R,Nasi Sdoi
10.1016/s0014-5793(01)03227-6keywords:
subject
Has Abstractpub_date
2002-01-02 00:00:00pages
50-6issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579301032276journal_volume
510pub_type
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