Abstract:
:The relationship between glutathione deficiency, glycogen metabolism and ascorbate synthesis was investigated in isolated murine hepatocytes. Glutathione deficiency caused by various agents increased ascorbate synthesis with a stimulation of glycogen breakdown. Increased ascorbate synthesis from UDP-glucose or gulonolactone could not be further affected by glutathione depletion. Fructose prevented the stimulated glycogenolysis and ascorbate synthesis caused by glutathione consumption. Reduction of oxidised glutathione by dithiothreitol decreased the elevated glycogenolysis and ascorbate synthesis in diamide or menadione treated hepatocytes. Our results suggest that a change in GSH/GSSG ratio seems to be a sufficient precondition of altering glycogenolysis and a consequent ascorbate synthesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Braun L,Csala M,Poussu A,Garzó T,Mandl J,Bánhegyi Gdoi
10.1016/0014-5793(96)00548-0subject
Has Abstractpub_date
1996-06-17 00:00:00pages
173-6issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(96)00548-0journal_volume
388pub_type
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