Abstract:
:A developmentally regulated exon has been identified in the 5'-alternatively spliced region of the human fast Troponin T (TnT) gene. Expressed in fetal (but not adult) muscle, this exon is homologous with the fetal exons recently described in the rabbit and rat fast TnT genes. They all exhibit a split codon organization and encode a highly acidic peptide. To determine if the splicing pathways, including the human fetal exon, are also conserved, we defined the major TnT splicing patterns in fetal muscle. They generate fetal TnT 1, fetal TnT 3, and TnT1f, and TnT3f, species previously described in rabbit and rat skeletal muscles.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Briggs MM,Maready M,Schmidt JM,Schachat Fdoi
10.1016/0014-5793(94)00729-2subject
Has Abstractpub_date
1994-08-15 00:00:00pages
37-40issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(94)00729-2journal_volume
350pub_type
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