Abstract:
:The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC alpha 1 and alpha 2 mRNAs is developmentally regulated in differentiating C2C12 myogenic cells. The alpha 1 mRNA is not detectable in the myoblast form of C2C12 cells while its expression is induced 20-fold in differentiated myotubes. In contrast, the alpha 2 mRNA is weakly expressed in myoblasts but is also induced upon myogenic differentiation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Varadi G,Orlowski J,Schwartz Adoi
10.1016/0014-5793(89)80787-2subject
Has Abstractpub_date
1989-07-03 00:00:00pages
515-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80787-2journal_volume
250pub_type
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