Developmental regulation of expression of the alpha 1 and alpha 2 subunits mRNAs of the voltage-dependent calcium channel in a differentiating myogenic cell line.

Abstract:

:The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC alpha 1 and alpha 2 mRNAs is developmentally regulated in differentiating C2C12 myogenic cells. The alpha 1 mRNA is not detectable in the myoblast form of C2C12 cells while its expression is induced 20-fold in differentiated myotubes. In contrast, the alpha 2 mRNA is weakly expressed in myoblasts but is also induced upon myogenic differentiation.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Varadi G,Orlowski J,Schwartz A

doi

10.1016/0014-5793(89)80787-2

subject

Has Abstract

pub_date

1989-07-03 00:00:00

pages

515-8

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(89)80787-2

journal_volume

250

pub_type

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