Abstract:
:We previously showed that the post-translational cleavage of alphav subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking alphav subunit cleavage by expression of alpha1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of the actin cytoskeleton upon cell attachment. These changes are associated with cell scattering and with a dramatic increase in cell migration to vitronectin. The alphav subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Berthet V,Rigot V,Nejjari M,Marvaldi J,Luis Jdoi
10.1016/s0014-5793(03)01467-4keywords:
subject
Has Abstractpub_date
2004-01-16 00:00:00pages
159-63issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303014674journal_volume
557pub_type
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