Abstract:
:The TOE1 gene was discovered as a target of the Egr1 transcription factor that participates in cell growth regulation through the upregulation of p21 and a cell cycle delay at the G2/M phase. We report here that TOE1 is able to bind to the p53 tumor suppressor protein, specifically interacting with the C terminal tetramerization domain of p53. We have further characterized this interaction through determination of binding kinetics using nanoporous optical interferometry and demonstrated that this interaction is capable of enhancing the transcriptional activity of p53-dependent gene targets. These results suggest a mechanistic role for TOE1 as a co-regulator of p53.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sperandio S,Tardito S,Surzycki A,Latterich M,de Belle Idoi
10.1016/j.febslet.2009.06.004subject
Has Abstractpub_date
2009-07-07 00:00:00pages
2165-70issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00445-1journal_volume
583pub_type
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