Abstract:
:The interferon inducible transmembrane (IFITM) proteins mediate several cellular processes such as homotypic cell adhesion functions of interferons (IFNs) and cellular anti-proliferative activities. We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor 1 (TEF-1/TEAD1) to the M-CAT like elements of its promoter. TEF-1 knock-down reduced the BAF complex-mediated activation of IFITM3 promoter. In the absence of the BAF complex, TEF-1 is repressive to IFITM3 expression. The regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cuddapah S,Cui K,Zhao Kdoi
10.1016/j.febslet.2007.12.033subject
Has Abstractpub_date
2008-01-23 00:00:00pages
391-7issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(07)01303-8journal_volume
582pub_type
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