Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRGl.


:The interferon inducible transmembrane (IFITM) proteins mediate several cellular processes such as homotypic cell adhesion functions of interferons (IFNs) and cellular anti-proliferative activities. We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor 1 (TEF-1/TEAD1) to the M-CAT like elements of its promoter. TEF-1 knock-down reduced the BAF complex-mediated activation of IFITM3 promoter. In the absence of the BAF complex, TEF-1 is repressive to IFITM3 expression. The regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes.




FEBS letters


Cuddapah S,Cui K,Zhao K




Has Abstract


2008-01-23 00:00:00














  • Temperature effects on the presteady-state and transport-associated currents of GABA cotransporter rGAT1.

    abstract::The effects of temperature on the gamma-aminobutyric acid (GABA) uptake and on the presteady-state and transport-associated currents of the GABA cotransporter, rat gamma-aminobutyric acid transporter 1 (rGAT1), have been studied using heterologous oocyte expression and voltage-clamp. Increasing temperature from 15 to ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Binda F,Bossi E,Giovannardi S,Forlani G,Peres A

    更新日期:2002-02-13 00:00:00

  • MiRNA let-7g regulates skeletal myoblast motility via Pinch-2.

    abstract::Post-transcriptional regulation of gene expression by RNA-binding proteins and by small non-coding RNAs plays an important role in cell biology. Our previous results show that in murine skeletal myoblasts, the expression of Pinch-2, a focal adhesion remodeling factor that regulates cell motility, is repressed by an RN...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Boudoukha S,Rivera Vargas T,Dang I,Kropp J,Cuvellier S,Gautreau A,Polesskaya A

    更新日期:2014-05-02 00:00:00

  • Expression of rice Ca(2+)-dependent protein kinases (CDPKs) genes under different environmental stresses.

    abstract::Ca(2+)-dependent protein kinases (CDPKs) play an essential role in plant Ca(2+)-mediated signal transduction. Twenty-nine CDPK genes have been identified in the rice genome through a complete search of genome and full-length cDNA databases. Eight of them were reported previously to be inducible by different stress sti...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wan B,Lin Y,Mou T

    更新日期:2007-03-20 00:00:00

  • Protein kinase A phosphorylates serine 267 in the homeodomain of engrailed-2 leading to decreased DNA binding.

    abstract::Engrailed-2 (En-2) belongs to an evolutionarily conserved family of DNA binding homeodomain-containing proteins that are expressed in mammalian brain during development. Here, we demonstrate that serine 267 in the homeodomain of En-2 is phosphorylated by protein kinase A (PKA) in forskolin-treated COS-7 cells. Further...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hjerrild M,Stensballe A,Jensen ON,Gammeltoft S,Rasmussen TE

    更新日期:2004-06-18 00:00:00

  • Prion protein is a component of the multimolecular signaling complex involved in T cell activation.

    abstract::In this study we analyzed the interaction of prion protein PrP(C) with components of glycosphingolipid-enriched microdomains in lymphoblastoid T cells. PrP(C) was distributed in small clusters on the plasma membrane, as revealed by immunoelectron microscopy. PrP(C) is present in microdomains, since it coimmunoprecipit...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mattei V,Garofalo T,Misasi R,Circella A,Manganelli V,Lucania G,Pavan A,Sorice M

    更新日期:2004-02-27 00:00:00

  • Low temperature completely rescues the function of two misfolded K ATP channel disease-mutants.

    abstract::The pancreatic ATP-sensitive potassium channels comprise two subunits: SUR1 and Kir6.2. Two SUR1 mutations, A116P and V187D, reduce channel activity causing persistent hyperinsulinemic hypoglycemia of infancy. We investigated whether these mutations cause temperature sensitive misfolding. We show that the processing d...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yang K,Fang K,Fromondi L,Chan KW

    更新日期:2005-08-01 00:00:00

  • Hormonal control of protein expression and mRNA levels of the MaxiK channel alpha subunit in myometrium.

    abstract::Large conductance voltage-dependent and Ca(2+)-modulated K(+) channels play a crucial role in myometrium contractility. Western blots and immunocytochemistry of rat uterine sections or isolated cells show that MaxiK channel protein signals drastically decrease towards the end of pregnancy. Consistent with a transcript...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Song M,Zhu N,Olcese R,Barila B,Toro L,Stefani E

    更新日期:1999-11-05 00:00:00

  • First tau repeat domain binding to growing and taxol-stabilized microtubules, and serine 262 residue phosphorylation.

    abstract::Tau phosphorylation plays a crucial role in microtubule stabilization and in Alzheimer's disease. To characterize the molecular mechanisms of tau binding on microtubules, we synthesized the peptide R1 (QTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQI), reproducing the first tau microtubule binding motif. We thermodynamically charac...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Devred F,Douillard S,Briand C,Peyrot V

    更新日期:2002-07-17 00:00:00

  • Interaction of trifluoperazine with porcine calmodulin 19F NMR and induced CD spectral studies.

    abstract::We have used 19F NMR and CD spectra to study interactions of TFP with CaM under various conditions where no aggregation of TFP occurs. It was found that TFP is bound to CaM in the absence of Ca2+ with Ka greater than 4 X 10(4) M in terms of 19F NMR of TFP and that KCl markedly influences the interaction of TFP with Ca...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Shimizu T,Hatano M

    更新日期:1983-08-22 00:00:00

  • Acquisition of essential somatic cell cycle regulatory protein expression and implied activity occurs at the second to third cell division in mouse preimplantation embryos.

    abstract::It is clear that G1-S phase control is exerted after the mouse embryo implants into the uterus 4.5 days after fertilization (E4.5); null mutants of genes that control cell cycle commitment such as max, rb (retinoblastoma), and dp1 are embryonic lethal after implantation with proliferation phenotypes. But, a number of ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Xie Y,Sun T,Wang QT,Wang Y,Wang F,Puscheck E,Rappolee DA

    更新日期:2005-01-17 00:00:00

  • Identification of the molecular basis for the functional difference between flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase.

    abstract::Flavonoid 3'-hydroxylase (F3'H) and flavonoid 3',5'-hydroxylase (F3'5'H) are cytochrome P450 enzymes and determine the B-ring hydroxylation pattern of flavonoids by introducing hydroxyl groups at the 3'- or the 3'- and 5'-position, respectively. Sequence identity between F3'H and F3'5'H is generally low since their di...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Seitz C,Ameres S,Forkmann G

    更新日期:2007-07-24 00:00:00

  • ADP-ribosylation of nuclear proteins is increased by phenobarbital. Identification of the ADP-ribosylated histone fractions in rat liver nuclei.

    abstract::Changes in the ADP-ribosylation of total proteins and purified histones of rat liver nuclei after phenobarbital treatment (80 mg/kg, 24 h) have been studied. The [32P]NAD incorporation into total trichloroacetic acid precipitated proteins, in histone Hl and in core histones was evaluated, the specific radioactivities ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bràz J,Lechner MC

    更新日期:1986-04-21 00:00:00

  • Differential expression of AMPA glutamate receptor mRNAs in the rat adrenal gland.

    abstract::Localisation of mRNA encoding the four AMPA glutamate receptor subunits in the rat adrenal gland was investigated using in situ hybridisation. GluR1 is found in the zona glomerulosa of the cortex, GluR3 in the remaining parts of the cortex, GluR2 in adrenal medullary cells and GluR4 at a very low level in the zona glo...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kristensen P

    更新日期:1993-10-11 00:00:00

  • Lack of adenosine deaminase deficiency in the mutant mouse wasted.

    abstract::The possibility that the mutant mouse wasted (wst/wst) may serve as an animal model for studies of severe combined immunodeficiency disease (SCID) and the role of adenosine deaminase (ADA, EC in adenosine metabolism were investigated. The specific activity of ADA in wst/wst compared with control mice was sign...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Geiger JD,Nagy JI

    更新日期:1986-11-24 00:00:00

  • BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.

    abstract::Germ-line mutations in BRCA1 are associated with an increased lifetime risk of developing breast and/or ovarian tumors. The BRCA1 gene product is a 220-kDa protein that contains a tandem of two BRCA1 C-terminal (BRCT) domains required for transcription. In an attempt to understand how BRCA1 exerts its function through...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yan J,Zhu J,Zhong H,Lu Q,Huang C,Ye Q

    更新日期:2003-10-09 00:00:00

  • A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells.

    abstract::The fluorescent Ca2+ indicator Fura 2 was used to monitor Ca2+ release induced by the Ins(1,4,5)P3-mobilizing agonist angiotensin II (Ag II), caffeine and 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tuBHQ), in intact bovine adrenal chromaffin cells. Under low external Ca2+ conditions, tuBHQ, Ag II and caffeine elicited...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Robinson IM,Burgoyne RD

    更新日期:1991-09-09 00:00:00

  • Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes.

    abstract::Mild sonication of eukaryotic cells produces native plasma membrane sheets that retain their docked organelles, cytoskeleton structures and cytoplasmic complexes. While the delicate organization of membranous protein complexes remains undisturbed, their inner plasmalemmel leaflet can be rapidly exposed to bathing solu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bar-On D,Winter U,Nachliel E,Gutman M,Fasshauer D,Lang T,Ashery U

    更新日期:2008-10-15 00:00:00

  • Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2.

    abstract::Nuclear cap-binding protein (CBP) 80/20-dependent translation (CT) is one of the targets for miRNA-mediated gene silencing. Here, we provide evidence that human argonaute 2 (Ago2) competes with CBP80/20 for cap-association, inhibiting CT and thus nonsense-mediated mRNA decay (NMD), which is tightly coupled to CT. Teth...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Choe J,Cho H,Chi SG,Kim YK

    更新日期:2011-09-02 00:00:00

  • Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid-potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment.

    abstract::In this study, we demonstrated that tissue inhibitor of metalloproteinases (TIMP) produced by human bone marrow stromal cell line KM-102 had erythroid-potentiating activity (EPA) which stimulates the proliferation of erythroid progenitor cells. We, then, propose a scheme for the bifunctional role of TIMP/EPA in hemato...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hayakawa T,Yamashita K,Kishi J,Harigaya K

    更新日期:1990-07-30 00:00:00

  • A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells.

    abstract::We have identified a cDNA encoding a 212 amino acid protein (Nm23-H5) with 27-31% identity to the human members of the nm23/nucleoside diphosphate (NDP) kinase gene family. The nm23-H5 gene is located on chromosome 5q23-31 and is transcribed as one main transcript of 1.1 kb which is highly and specifically expressed i...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Munier A,Feral C,Milon L,Pinon VP,Gyapay G,Capeau J,Guellaen G,Lacombe ML

    更新日期:1998-09-04 00:00:00

  • Molecular mechanism of inhibition of mammalian protein synthesis by some four-chain agglutinins. Proposal of an extended classification of plant ribosome-inactivating proteins (rRNA N-glycosidases).

    abstract::The four chain agglutinins from Abrus precatorius, Viscum album and Ricinus communis promote depurination of the 28 S rRNA from rabbit reticulocyte ribosomes characteristic of the common ribosome-inactivating proteins (RIPs). These agglutinins inhibited mammalian protein synthesis at nanomolar concentrations but they ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Citores L,Ferreras JM,Iglesias R,Carbajales ML,Arias FJ,Jiménez P,Rojo MA,Girbés T

    更新日期:1993-08-23 00:00:00

  • Novel type Arabidopsis thaliana H(+)-PPase is localized to the Golgi apparatus.

    abstract::Vacuolar H(+)-PPase, a membrane bound proton-translocating pyrophosphatase found in various species including plants, some protozoan and prokaryotes, has been demonstrated to be localized to the vacuolar membrane in plants. Using a GUS reporter system and a green fluorescent protein (GFP) fusion protein, we investigat...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mitsuda N,Enami K,Nakata M,Takeyasu K,Sato MH

    更新日期:2001-01-12 00:00:00

  • Permeabilizing action of an antimicrobial lactoferricin-derived peptide on bacterial and artificial membranes.

    abstract::A synthetic peptide (23 residues) that includes the antibacterial and lipopolysaccharide-binding regions of human lactoferricin, an antimicrobial sequence of lactoferrin, was used to study its action on cytoplasmic membrane of Escherichia coli 0111 and E. coli phospholipid vesicles. The peptide caused a depolarization...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Aguilera O,Ostolaza H,Quirós LM,Fierro JF

    更新日期:1999-12-03 00:00:00

  • High phosphorylation of HBV core protein by two alpha-type CK2-activated cAMP-dependent protein kinases in vitro.

    abstract::Two alpha-type CK2-activated PKAs (CK2-aPKAIalpha and CK2-aPKAIIalpha) were biochemically characterized in vitro using GST-HBV core fusion protein (GST-Hcore) and GST-Hcore157B as phosphate acceptors. It was found that (i), in the absence of cAMP, these two CK2-aPKAs phosphorylated both Ser-170 and Ser-178 on GST-Hcor...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Enomoto M,Sawano Y,Kosuge S,Yamano Y,Kuroki K,Ohtsuki K

    更新日期:2006-02-06 00:00:00

  • Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.

    abstract::Drosophila PTEN (dPTEN) plays indispensable roles in the development of Drosophila melanogaster by controlling cell size and number. Although three potential spliced forms of dPTEN have been isolated, functional distinction among these forms remains elusive. In this study, we demonstrate that all spliced forms of dPTE...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Maehama T,Kosaka N,Okahara F,Takeuchi K,Umeda M,Dixon JE,Kanaho Y

    更新日期:2004-05-07 00:00:00

  • Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activity.

    abstract::The role of TlyA, TlyB and TlyC proteins in the biology of Leptospira is still uncertain. Although these proteins have been considered as putative hemolysins, we demonstrate that leptospiral recombinant TlyB and TlyC do not possess hemolytic activity. However, further experiments showed that TlyC is a surface-exposed ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Carvalho E,Barbosa AS,Gómez RM,Cianciarullo AM,Hauk P,Abreu PA,Fiorini LC,Oliveira ML,Romero EC,Gonçales AP,Morais ZM,Vasconcellos SA,Ho PL

    更新日期:2009-04-17 00:00:00

  • A stimulating effect of guanyl nucleotides on the rat-liver soluble cyclic GMP high-affinity phosphodiesterase activity.

    abstract::The high affinity (low Km) cyclic GMP phosphodiesterase (PDE) is activated by GTP, while the cyclic AMP PDE is not. GTP and its hydrolysis-resistant analogue, guanylylimidodiphosphate (GppNHp), display a half-maximal stimulating effect at almost the same concentration (5 X 10(-6) M). The GTP stimulating effect is not ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Spina A,Chiosi E,Paolisso G,Laurenza A,Illiano G

    更新日期:1983-07-04 00:00:00

  • Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei.

    abstract::Trypanosomes are unicellular parasites and like all decent parasites, they try to obtain from the host as much material as possible, including lipids. However, the needs of a parasite are not always the same as those of the host, and therefore, mostly, some biosynthetic work still has to be done by the parasite itself...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: van Hellemond JJ,Tielens AG

    更新日期:2006-10-09 00:00:00

  • The effect of the natural protein inhibitor on H+-ATPase hepatoma 22a mitochondria.

    abstract::The uncoupler-induced inactivation of H+-ATPase in hepatoma 22a and mouse liver mitochondria has been studied. The dependence of this process on delta microH, and pH and ATP was established. The inactivated ATPase could be reactivated at alkaline pH values in the absence of ATP. These data indicate that the inactivati...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chernyak BV,Dukhovich VF,Khodjaev EYu

    更新日期:1987-05-11 00:00:00

  • Redundancy and divergence in the amyloid precursor protein family.

    abstract::Gene duplication provides genetic material required for functional diversification. An interesting example is the amyloid precursor protein (APP) protein family. The APP gene family has experienced both expansion and contraction during evolution. The three mammalian members have been studied quite extensively in combi...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Shariati SA,De Strooper B

    更新日期:2013-06-27 00:00:00