Abstract:
:Neurons grow during development and extend long axons to make contact with their targets with the help of an intrinsic program of axonal growth as well as a range of extrinsic cues and a permissive milieu. Injury events in adulthood induce some neuron types to revert to a regenerative state in the peripheral nervous system (PNS). Neurons from the central nervous system (CNS), however, reveal a much lower capacity for regenerative growth. A number of intrinsic regeneration-promoting mechanisms have been described, including priming by calcium waves, epigenetic modifications, local mRNA translation, and dynein-driven retrograde transport of transcription factors (TFs) or signaling complexes that lead to TF activation and nuclear translocation. Differences in the availability or recruitment of these mechanisms may partially explain the limited response of CNS neurons to injury.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Doron-Mandel E,Fainzilber M,Terenzio Mdoi
10.1016/j.febslet.2015.04.046subject
Has Abstractpub_date
2015-06-22 00:00:00pages
1669-77issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(15)00304-Xjournal_volume
589pub_type
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