Abstract:
:When the eicosapentaenoic acid (EPA)-deficient mutant strain IK-1Delta8 of the marine EPA-producing Shewanella marinintestina IK-1 was treated with various concentrations of hydrogen peroxide (H(2)O(2)), its colony-forming ability decreased more than that of the wild type. Protein carbonylation, induced by treating cells with 0.01 mM H(2)O(2) under bacteriostatic conditions, was enhanced only in cells lacking EPA. The amount of cells recovered from the cultures was decreased more significantly by the presence of H(2)O(2) for cells lacking EPA than for those producing EPA. Treatment of the cells with 0.1 mM H(2)O(2) resulted in much lower intracellular concentrations of H(2)O(2) being consistently detected in cells with EPA than in those without EPA. These results suggest that cellular EPA can directly protect cells against oxidative damage by shielding the entry of exogenously added H(2)O(2) in S. marinintestina IK-1.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nishida T,Morita N,Yano Y,Orikasa Y,Okuyama Hdoi
10.1016/j.febslet.2007.07.065subject
Has Abstractpub_date
2007-09-04 00:00:00pages
4212-6issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00841-1journal_volume
581pub_type
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