Abstract:
:The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yoshinari K,Kobayashi K,Moore R,Kawamoto T,Negishi Mdoi
10.1016/s0014-5793(03)00720-8keywords:
subject
Has Abstractpub_date
2003-07-31 00:00:00pages
17-20issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303007208journal_volume
548pub_type
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