Abstract:
:The hemoregulatory peptide PyroGlu-Glu-Asp-Cys-Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Gi alpha proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Gi alpha sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N-terminus. It is postulated that these peptides may interfere with signal transduction mediated by Gi alpha proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Laerum OD,Frostad S,Tøn HI,Kamp Ddoi
10.1016/0014-5793(90)81106-xsubject
Has Abstractpub_date
1990-08-20 00:00:00pages
11-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(90)81106-Xjournal_volume
269pub_type
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