Abstract:
:Apoptosis specific proteins (ASP) are expressed in the cytoplasm of cultured mammalian cells of various lineages following induction of apoptosis. The cDNA encoding ASP has been cloned from a human expression library and has significant homology to the Saccharomyces cerevisiae APG5 gene which is essential for yeast autophagy. The ASP gene, known as hAPG5, can be transcribed to give mRNAs of 3.3 kbp, 2.5 kbp and 1.8 kbp which are present at comparable levels in viable and apoptotic cells, demonstrating that protein expression must be regulated at the translational level. These data indicate a possible relationship between apoptosis and autophagy and suggest evolutionary conservation in mammalian apoptosis of a degradative process present in yeast.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hammond EM,Brunet CL,Johnson GD,Parkhill J,Milner AE,Brady G,Gregory CD,Grand RJdoi
10.1016/s0014-5793(98)00266-xsubject
Has Abstractpub_date
1998-04-03 00:00:00pages
391-5issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00266-Xjournal_volume
425pub_type
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