Abstract:
:Lewy bodies (LBs) are the pathologic hallmark of Parkinson's disease. Recent studies revealed that LBs exhibit several morphologic and molecular similarities to aggresomes. Aggresomes are perinuclear aggregates representing intracellular deposits of misfolded proteins. Recently, valosin-containing protein (VCP) was one of the components of LBs, suggesting its involvement in LB formation. Here, we showed the localization of VCP in aggresomes induced by a proteasome inhibitor in cultured cells. Cells overexpressing mutant VCP (K524M: D2) showed reduced aggresome formation relative to those overexpressing wild-type and mutant (K251M: D1) VCPs. Our findings suggest that the D2 domain is involved in aggresome formation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kitami MI,Kitami T,Nagahama M,Tagaya M,Hori S,Kakizuka A,Mizuno Y,Hattori Ndoi
10.1016/j.febslet.2005.12.044keywords:
subject
Has Abstractpub_date
2006-01-23 00:00:00pages
474-8issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01519-Xjournal_volume
580pub_type
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