Abstract:
:Gap junction channels may be comprised of either connexin or pannexin proteins (innexins and pannexins). Membrane topologies of both families are similar, but sequence similarity is lacking. Recently, connexin-like sequences have been identified in mammalian and zebrafish genomes that have only four conserved cysteines in the extracellular domains (Cx23), a feature of the pannexins. Phylogenetic analyses of the non-canonical "C4" connexins reveal that these sequences are indeed connexins. Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Iovine MK,Gumpert AM,Falk MM,Mendelson TCdoi
10.1016/j.febslet.2007.11.079subject
Has Abstractpub_date
2008-01-23 00:00:00pages
165-70issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(07)01233-1journal_volume
582pub_type
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