Abstract:
:In Alzheimer's disease and related dementias, human tau protein aggregates into paired helical filaments and neurofibrillary tangles. However, such tau aggregates have not yet been demonstrated in transgenic mouse models of the disease. One of the possible explanations would be that mouse tau has different properties which prevents it from aggregating. We have cloned several murine tau isoforms, containing three or four repeats and different combinations of inserts, expressed them in Escherichia coli and show here that they can all be assembled into paired helical filaments similar to those in Alzheimer's disease, using the same protocols as with human tau. Therefore, the absence of pathologically aggregated tau in transgenic mice cannot be explained by intrinsic differences in mouse tau protein and instead must be explained by other as yet unknown factors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kampers T,Pangalos M,Geerts H,Wiech H,Mandelkow Edoi
10.1016/s0014-5793(99)00522-0keywords:
subject
Has Abstractpub_date
1999-05-14 00:00:00pages
39-44issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00522-0journal_volume
451pub_type
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