Abstract:
:Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kramer ER,Liss Bdoi
10.1016/j.febslet.2015.11.006subject
Has Abstractpub_date
2015-12-21 00:00:00pages
3760-72issue
24 Pt Aeissn
0014-5793issn
1873-3468pii
S0014-5793(15)00977-1journal_volume
589pub_type
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