Abstract:
:Under physiological conditions significant amounts of low-density lipoprotein LDL particles ar taken up by cells independently of specific high-affinity LDL receptors (apo-B receptors). Previously it was established that some cells contain surface sites capable of binding liposomes. We proposed that liposome-binding sites could contribute to LDL interaction with the cell surface via phospholipid molecules of LDL particles. To check this hypothesis we studied the competitive interaction of human LDL and DPPC liposomes with mouse embryo fibroblasts depleted of apo-B receptors by preliminary incubation with LDL. We have found that after removal of the liposome-binding sites from cell lamellae these areas of the cell surface lose their ability to bind LDL.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Galkina SI,Ivanov VV,Preobrazhensky SN,Margolis LB,Bergelson LDdoi
10.1016/0014-5793(91)80006-osubject
Has Abstractpub_date
1991-08-05 00:00:00pages
19-22issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80006-Ojournal_volume
287pub_type
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