Abstract:
:A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expression of fad104 was detected in adipocyte differentiable 3T3-L1 cells but not observed in the non-adipogenic cell line NIH-3T3. Moreover, the ability of 3T3-L1 cells to differentiate declined with the knockdown of fad104 by RNA interference, strongly indicating that fad104 functions as a positive regulator of adipogenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tominaga K,Kondo C,Johmura Y,Nishizuka M,Imagawa Mdoi
10.1016/j.febslet.2004.09.062keywords:
subject
Has Abstractpub_date
2004-11-05 00:00:00pages
49-54issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579304011949journal_volume
577pub_type
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