Abstract:
:2-Deoxyglucose and 5-thioglucose, in the same fashion as glucose, cause the inactivation of the rat hepatocyte glycogen phosphorylase and the activation of glycogen synthase. However, 6-deoxyglucose and 1,5-anhydroglucitol inactivate phosphorylase without increasing the activation state of glycogen synthase. With 3-O-methylglucose no changes in the activity of these enzymes occurred. These results prove that while glucose is the molecule that triggers the inactivation of phosphorylase, glucose 6-phosphate is the signal for glucose synthase activation and that a metabolite control of the activation state of glycogen synthase is operative in hepatocytes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Carabaza A,Ciudad CJ,Baqué S,Guinovart JJdoi
10.1016/0014-5793(92)80381-psubject
Has Abstractpub_date
1992-01-20 00:00:00pages
211-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(92)80381-Pjournal_volume
296pub_type
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