Altered chemotaxis of Bacillus sphaericus L-ethionine-resistant sporulation mutant. A probable link between chemotaxis and sporulation.

abstract：:Fibromodulin and lumican are closely related members of the extracellular matrix leucine-rich repeat glycoprotein/proteoglycan family. Similar to decorin, another member of this protein family, they bind to fibrillar collagens and function in the assembly of the collagen network in connective tissues. We have studied ...

journal_title：FEBS letters

authors： Svensson L,Närlid I,Oldberg A

更新日期：2000-03-24 00:00:00

abstract：:We have used a gene replacement strategy to delete the previously isolated gene [(1987) EMBO J. 6, 2825-2833] for the cytochrome c oxidase subunit I from Paracoccus denitrificans. The resulting mutant was still able to synthesize active cytochrome c oxidase. This led us to look for another locus which could completely...

journal_title：FEBS letters

authors： Raitio M,Pispa JM,Metso T,Saraste M

更新日期：1990-02-26 00:00:00

abstract：:We studied the effect of acrolein, an alpha,beta-unsaturated aldehyde that causes adduct-modification of lysine, cysteine, and histidine residues, on antithrombin, a key anticoagulant serpin. Intrinsic fluorescence, functionality (anti-FXa and anti-IIa activity), heparin affinity and conformational features of plasma ...

journal_title：FEBS letters

authors： Martínez-Martínez I,Ordóñez A,Guerrero JA,Pedersen S,Miñano A,Teruel R,Velázquez L,Kristensen SR,Vicente V,Corral J

更新日期：2009-10-06 00:00:00

abstract：:A large protein complex (approx. 2000 kDa) was found in the cytosol of the hyperthermophilic archaebacterium Staphylothermus marinus. The purified protein was shown to be a homomultimer of 93 kDa subunits, the primary structure of which was determined by nucleotide sequence analysis. The protein belongs to the family ...

journal_title：FEBS letters

authors： Cicicopol C,Peters J,Kellermann J,Baumeister W

更新日期：1994-12-19 00:00:00

abstract：:The interactions between the polyanionic ligands phosphate and sulphate and the type II dehydroquinases from Streptomyces coelicolor and Mycobacterium tuberculosis have been characterised using a combination of structural and kinetic methods. From both approaches, it is clear that interactions are more complex in the ...

journal_title：FEBS letters

authors： Evans LD,Roszak AW,Noble LJ,Robinson DA,Chalk PA,Matthews JL,Coggins JR,Price NC,Lapthorn AJ

更新日期：2002-10-23 00:00:00

abstract：:Daunorubicin induces apoptosis in myeloid leukemia cells by activation of neutral sphingomyelinase and ceramide generation occurring 4-10 min after daunorubicin addition. We show here that daunorubicin is able to increase the phosphoinositide 3-kinase activity and enhance intracellular phosphoinositide 3-kinase lipid ...

journal_title：FEBS letters

authors： Plo I,Bettaïeb A,Payrastre B,Mansat-De Mas V,Bordier C,Rousse A,Kowalski-Chauvel A,Laurent G,Lautier D

更新日期：1999-06-11 00:00:00

abstract：:The binding of L-[35S]methionine in vivo labelled CryIC toxin to its receptor in brush border membrane vesicle (BBMV's) prepared from Spodoptera littoralis and Bombyx mori was studied. Both insect species were highly susceptible to the CryIC toxin in bioassays, B. mori being 7-fold more sensitive to CryIC than S. litt...

journal_title：FEBS letters

authors： Sanchis V,Chaufaux J,Pauron D

更新日期：1994-10-24 00:00:00

abstract：:The major anthocyanin in A. thaliana is a cyanidin derivative modified by glycosylation as well as by the addition of three acyl moieties: malonyl, p-coumaroyl, and sinapoyl. We have isolated a member of the BAHD acyltransferase family which catalyzes this malonylation reaction by combining a reverse genetics approach...

journal_title：FEBS letters

authors： D'Auria JC,Reichelt M,Luck K,Svatos A,Gershenzon J

更新日期：2007-03-06 00:00:00

abstract：:The lipid A structure of the Gram-negative bacterium Helicobacter mustelae, a ferret gastric pathogen responsible for the onset of gastric diseases in its host, was investigated. Two variant lipid A structures were found in the same strain. One structure contained a bisphosphorylated beta-(1-->6)-linked D-glucosamine ...

journal_title：FEBS letters

authors： Thérisod H,Monteiro MA,Perry MB,Caroff M

更新日期：2001-06-15 00:00:00

abstract：:The incorporation of carbon into the carbon monoxide and cyanide ligands of [NiFe]-hydrogenases has been investigated by using (13)C labelling in infrared studies of the Allochromatium vinosum enzyme and by (14)C labelling experiments with overproduced Hyp proteins from Escherichia coli. The results suggest that the b...

journal_title：FEBS letters

authors： Roseboom W,Blokesch M,Böck A,Albracht SP

更新日期：2005-01-17 00:00:00

abstract：:Myogenesis is conducted by transcription factors including MyoD and myogenin. Myogenin is known to be polyubiquitinated by SCF (Skp1/Cullin 1/F-box protein) followed by proteasomal degradation, though the participating F-box protein is remaining unidentified. In this study, we found that myogenin in differentiated myo...

journal_title：FEBS letters

authors： Jogo M,Shiraishi S,Tamura TA

更新日期：2009-09-03 00:00:00

abstract：:The nitration of tyrosine residues in protein occurs through the action of reactive oxygen and nitrogen species and is considered a marker of oxidative stress under pathological conditions. The most active nitrating species so far identified is peroxynitrite, the product of the reaction between nitric oxide and supero...

journal_title：FEBS letters

authors： Mallozzi C,Di Stasi AM,Minetti M

更新日期：2001-08-17 00:00:00

abstract：:A short form of Escherichia coli translational initiation factor IF3, repeatedly found both in vivo and in vitro, lacking the positively charged N-terminal hexapeptide has been produced by mild trypsinization. The properties of this short form of IF3 have been studied. Compared to the long native form of the factor, t...

journal_title：FEBS letters

authors： Lammi M,Pon CL,Gualerzi CO

更新日期：1987-05-04 00:00:00

abstract：:The effort to understand the mechanism of uncoupling by UCP has devolved into two models - the fatty acid protonophore model and the proton buffering model. Evidence for each hypothesis is summarized and evaluated. We also evaluate the obligatory requirement for fatty acids in UCP1-mediated uncoupling and the question...

journal_title：FEBS letters

authors： Garlid KD,Jabůrek M,Jezek P

更新日期：1998-10-30 00:00:00

abstract：:Eukaryotic porins are a group of membrane proteins whose best known role is to form an aqueous pore channel in the mitochondrial outer membrane. As opposed to the bacterial porins (a large family of protein whose 3D structure has been determined by X-ray diffraction), the structure of eukaryotic porins (also termed VD...

journal_title：FEBS letters

authors： Casadio R,Jacoboni I,Messina A,De Pinto V

更新日期：2002-06-05 00:00:00

abstract：:Eleven cloned hybridomas which secrete antibodies to acetylcholine receptors from human muscle have been prepared. All of these monoclonal antibodies to have the same basic specificity as shown by competition for binding to the main immunogenic region on the receptor, but these antibodies differ in fine specificity as...

journal_title：FEBS letters

authors： Tzartos S,Langeberg L,Hochschwender S,Lindstrom J

更新日期：1983-07-11 00:00:00

abstract：:We have investigated the possible role of selected negatively-charged amino acids of the sodium and chloride-coupled GABA transporter GAT-1 on sodium binding. These residues located adjacent to putative transmembrane domains and which are conserved throughout the large superfamily of neurotransmitter transporters were...

journal_title：FEBS letters

authors： Keshet GI,Bendahan A,Su H,Mager S,Lester HA,Kanner BI

更新日期：1995-08-28 00:00:00

abstract：:Phospholipase A2 (PLA2) from human pancreas, designated hPLA2-I, functions as a digestive enzyme. Interestingly, the present study demonstrated that the mature form of hPLA2-I stimulated the growth of a human pancreatic cancer cell line MIAPaCa-2, whereas the pro-form was ineffective. PLA2s from Laticauda semifasciata...

journal_title：FEBS letters

authors： Hanada K,Kinoshita E,Itoh M,Hirata M,Kajiyama G,Sugiyama M

更新日期：1995-10-02 00:00:00

abstract：:A protein-tyrosine phosphatase LC-PTP is preferentially expressed in hematopoietic cells and is an early response gene in lymphokine stimulated cells. Here, we found the LC-PTP mRNA induction by IL-2 was markedly inhibited by several tyrosine kinase inhibitors. The induction required both the acidic and serine-rich re...

journal_title：FEBS letters

authors： Adachi M,Torigoe T,Sekiya M,Minami Y,Taniguchi T,Hinoda Y,Yachi A,Reed JC,Imai K

更新日期：1995-09-18 00:00:00

abstract：:Stimulation of mas-oncogene transfected 401L-C3 cells by angiotensins leads to the production of inositol phosphates. This response shows dose dependence, and has an apparent rank order of potency angiotensin III greater than or equal to angiotensin II much greater than angiotensin I. Preincubation with 12-O-tetradeca...

journal_title：FEBS letters

authors： Jackson TR,Hanley MR

更新日期：1989-07-17 00:00:00

abstract：:A complete cDNA clone encoding human cholesterol 7 alpha-hydroxylase has been isolated using a rat P-450ch7 alpha cDNA insert [(1989) FEBS Lett. 257, 97-100] as a probe and totally sequenced. The cDNA contained 1512-base pair open reading frame encoding 504 amino acid residues (Mr 57,630), 39-base pair 5'-untranslated...

journal_title：FEBS letters

authors： Noshiro M,Okuda K

更新日期：1990-07-30 00:00:00

abstract：:Treatment of human vascular smooth muscle cells (SMC) with human alpha-thrombin greatly increased DNA synthesis and cell proliferation. Both the integrity of the catalytic site and that of the anion binding exosite were required for expression of this activity. Experiments employing Northerns indicated induction of c-...

journal_title：FEBS letters

authors： Kanthou C,Parry G,Wijelath E,Kakkar VV,Demoliou-Mason C

更新日期：1992-12-14 00:00:00

abstract：:FabH (beta-ketoacyl-acyl carrier protein synthase III) is unique in that it initiates fatty acid biosynthesis, is inhibited by long-chain fatty acids providing means for feedback control of the process, and dictates the fatty acid profile of the organism by virtue of its substrate specificity. We report the crystal st...

journal_title：FEBS letters

authors： Gajiwala KS,Margosiak S,Lu J,Cortez J,Su Y,Nie Z,Appelt K

更新日期：2009-09-03 00:00:00

abstract：:Hell's Gate globin I (HGbI), a heme-containing protein structurally homologous to mammalian neuroglobins, has been identified from an acidophilic and thermophilic obligate methanotroph, Methylacidiphilum infernorum. HGbI has very high affinity for O(2) and shows barely detectable autoxidation in the pH range of 5.2-8....

journal_title：FEBS letters

authors： Teh AH,Saito JA,Baharuddin A,Tuckerman JR,Newhouse JS,Kanbe M,Newhouse EI,Rahim RA,Favier F,Didierjean C,Sousa EH,Stott MB,Dunfield PF,Gonzalez G,Gilles-Gonzalez MA,Najimudin N,Alam M

更新日期：2011-10-20 00:00:00

abstract：:Tau is reversibly hyperphosphorylated in the mouse brain by starvation or cold water swimming. Here, we report tau phosphorylation in the hippocampus of normal mouse after ether anesthesia, known to trigger typical stress reactions. Robust phosphorylation of tau was observed immediately and 10min after ether vapor exp...

journal_title：FEBS letters

authors： Ikeda Y,Ishiguro K,Fujita SC

更新日期：2007-03-06 00:00:00

abstract：:For understanding the mechanism(s) relating inflammation to corticosteroid action, the effect of tumour necrosis factor-alpha (TNF-alpha) on 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the enzyme regulating access of 11beta-hydroxycorticosteroids to receptors, was studied in LLC-PK(1) cells. We observed ...

journal_title：FEBS letters

authors： Heiniger CD,Rochat MK,Frey FJ,Frey BM

更新日期：2001-11-02 00:00:00

abstract：:The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the...

journal_title：FEBS letters

authors： Yoshinari K,Kobayashi K,Moore R,Kawamoto T,Negishi M

更新日期：2003-07-31 00:00:00

abstract：:We demonstrated that unmodified and modified (phosphorothioate) oligonucleotides prevent cDNA synthesis by AMV or HIV reverse transcriptases. Antisense oligonucleotide/RNA hybrids specifically arrest primer extension. The blockage involves the degradation of the RNA fragment bound to the antisense oligonucleotide by t...

journal_title：FEBS letters

authors： Hatta T,Kim SG,Nakashima H,Yamamoto N,Sakamoto K,Yokoyama S,Takaku H

更新日期：1993-09-13 00:00:00

abstract：:We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum an...

journal_title：FEBS letters

authors： Spencer JP,Chowrimootoo G,Choudhury R,Debnam ES,Srai SK,Rice-Evans C

更新日期：1999-09-17 00:00:00

abstract：:Polymyxin B (PXB), a cyclic peptide antibiotic, in concentrations 0.1-3.0 mg/ml (0.08-4.0 mmol/l), inhibited the K+ efflux induced by opening of the Ca2+-activated K+ channel (the Gárdos effect) in intact human red blood cells. The inhibition was observed when the Gárdos effect was elicited by Ca2+ in the presence of ...

journal_title：FEBS letters

authors： Varecka L,Peterajová E,Pogády J

更新日期：1987-12-10 00:00:00