Abstract:
:We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Spencer JP,Chowrimootoo G,Choudhury R,Debnam ES,Srai SK,Rice-Evans Cdoi
10.1016/s0014-5793(99)01160-6keywords:
subject
Has Abstractpub_date
1999-09-17 00:00:00pages
224-30issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(99)01160-6journal_volume
458pub_type
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