Abstract:
:The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane. Here, we demonstrate the widespread occurrence of TRAP alpha in eukaryotes as indicated by its existence in man, fish and plants. Despite the fact that the sequence homology is much lower than for other proteins in the translocation site, the overall topology, the location of the glycosylation sites and, most interestingly, the distribution of charges are conserved. These data indicate that the TRAP complex has a ubiquitous function.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hartmann E,Prehn Sdoi
10.1016/0014-5793(94)00693-8subject
Has Abstractpub_date
1994-08-08 00:00:00pages
324-6issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(94)00693-8journal_volume
349pub_type
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