Abstract:
:Mutations in PTEN-induced putative kinase 1 (PINK1) cause recessive form of Parkinson's disease (PD). PINK1 acts upstream of parkin, regulating mitochondrial integrity and functions. Here, we show that PINK1 in combination with parkin results in the perinuclear mitochondrial aggregation followed by their elimination. This elimination is reduced in cells expressing PINK1 mutants with wild-type parkin. Although wild-type PINK1 localizes in aggregated mitochondria, PINK1 mutants localization remains diffuse and mitochondrial elimination is not observed. This phenomenon is not observed in autophagy-deficient cells. These results suggest that mitophagy controlled by the PINK1/parkin pathway might be associated with PD pathogenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kawajiri S,Saiki S,Sato S,Sato F,Hatano T,Eguchi H,Hattori Ndoi
10.1016/j.febslet.2010.02.016subject
Has Abstractpub_date
2010-03-19 00:00:00pages
1073-9issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00110-9journal_volume
584pub_type
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