Abstract:
:The Bacillus thuringiensis Cry toxin causes swelling and necrosis in insect cells, but the route(s) and significance of the water influx involved in its cytotoxicity are unclear. Here, we assessed the role of aquaporins (AQPs), known as water channels, in Cry toxin intoxication. An AQP inhibitor did not interfere with any known process to form the toxin pore, but it diminished the cell swelling and loss of membrane integrity induced by the Cry toxin. Overexpression of AQPs facilitated water influx and cytotoxicity. Our results demonstrate that water influx via aquaporin directly determines necrotic cell death induced by the Cry toxin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Endo H,Azuma M,Adegawa S,Kikuta S,Sato Rdoi
10.1002/1873-3468.12506subject
Has Abstractpub_date
2017-01-01 00:00:00pages
56-64issue
1eissn
0014-5793issn
1873-3468journal_volume
591pub_type
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