Abstract:
:Part of the cytoplasmic domain of a human desmoglein, Dsg1, a cadherin-like protein found in desmosomes of epithelial cells, has been visualised by electron microscopy. The cloned fragment contains five repeats of a 29 +/- 4 residue sequence unique to desmogleins, followed by a glycine-rich region. In rotary shadowed preparations the molecule consists of a globular head attached to a thin tail, the latter perhaps corresponding to the glycine-rich region. This portion of the molecule is thought to span the width of the inner dense plaque. The structure and dimensions concur well to the configuration deduced from the protein sequence.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rutman AJ,Buxton RS,Burdett IDdoi
10.1016/0014-5793(94)01049-8subject
Has Abstractpub_date
1994-10-17 00:00:00pages
194-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(94)01049-8journal_volume
353pub_type
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