Abstract:
:In cultured rat pituitary gonadotrophs, gonadotropin-releasing hormone (GnRH) induces rapid hyperpolarization of the cell membrane and causes cessation of the spontaneous electrical activity present in non-stimulated cells. This initial response to GnRH is followed by slow oscillations of membrane potential (Vm) which often exhibit brief bursts of action potentials (AP) fired from the peak of the oscillations. The hyperpolarization waves are synchronous with GnRH-induced elevations of cytoplasmic Ca2+ concentration ([Ca2+]i), such that Vm maxima alternate with the peak values of [Ca2+]i. The Vm oscillations result from repetitive activation of apamin-sensitive K+ channels by cytoplasmic Ca2+. Thus, GnRH activation of Ca2+ mobilization can generate a bursting pattern of membrane potential through the activation of K+ channels against a background of spontaneous electrical activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kukuljan M,Stojilković SS,Rojas E,Catt KJdoi
10.1016/0014-5793(92)80201-qkeywords:
subject
Has Abstractpub_date
1992-04-13 00:00:00pages
19-22issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(92)80201-Qjournal_volume
301pub_type
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