Abstract:
:The T-cell antigen receptor (TCR) is a multisubunit transmembrane complex that mediates the antigen-specific activation of T cells. Using a variety of techniques, several research groups have shown that TCRs are at least partially pre-clustered before antigen binding. These new findings are contradictory to the "classical" view, according to which TCRs are randomly distributed on the cell surface and only associate upon antigen binding. In this review we try to answer the following questions: What are the experimental evidences for the existence of pre-clustered TCRs? How can the TCR pre-clusters be activated upon antigen binding? Which functional consequences for T-cell activation arise from the pre-clustering of TCRs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Molnár E,Deswal S,Schamel WWdoi
10.1016/j.febslet.2010.09.004subject
Has Abstractpub_date
2010-12-15 00:00:00pages
4832-7issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00713-1journal_volume
584pub_type
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