Abstract:
:We describe the identification and characterization of the BMH1 gene from the yeast Saccharomyces cerevisiae. The gene encodes a putative protein of 292 amino acids which is more than 50% identical with the bovine brain 14-3-3 protein and proteins isolated from sheep brain which are strong inhibitors of protein kinase C. Disruption mutants and strains with the BMH1 gene on multicopy plasmids have impaired growth on minimal medium with glucose as carbon source, i.e. a 30-50% increase in generation time. These observations suggest a regulatory function of the bmh1 protein. In contrast to strains with an intact or a disrupted BMH1 gene, strains with the BMH1 gene on multicopy plasmids hardly grew on media with acetate or glycerol as carbon source.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
van Heusden GP,Wenzel TJ,Lagendijk EL,de Steensma HY,van den Berg JAdoi
10.1016/0014-5793(92)80426-hkeywords:
subject
Has Abstractpub_date
1992-05-11 00:00:00pages
145-50issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(92)80426-Hjournal_volume
302pub_type
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