Abstract:
:Cardiac toxicity is an uncommon but potentially serious complication of cancer therapy, especially with anthracyclines. One of the most effective anticancer drugs is doxorubicin, but its value is limited by the risk of developing cardiomyopathy and ventricular arrhythmia. When applied to a network of periodically contracting cardiomyocytes in culture, doxorubicin induces rhythm disturbances. Using a novel rapid assay based on non-invasive ion-conductance microscopy we show that the beta-antagonist esmolol can restore rhythm in doxorubicin-treated cultures of cardiomyocytes. Moreover, esmolol pre-treatment can protect the culture from doxorubicin-induced arrhythmia.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gorelik J,Vodyanoy I,Shevchuk AI,Diakonov IA,Lab MJ,Korchev YEdoi
10.1016/s0014-5793(03)00743-9keywords:
subject
Has Abstractpub_date
2003-07-31 00:00:00pages
74-8issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303007439journal_volume
548pub_type
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