Abstract:
:Mitochondrial thioredoxin (mtTrx) can be oxidized in response to inducers of oxidative stress; yet the functional consequences of the oxidation have not been determined. This study evaluated the redox status of mtTrx and its association to oxidant-induced apoptosis. Results showed that mtTrx was oxidized after exposure to peroxides and diamide. Overexpression of mtTrx protected against diamide-induced oxidation and cytotoxicity. Oxidation of mtTrx was also achieved by knocking down its reductase; and lead to increased susceptibility to cell death. The data indicate that the redox status of mtTrx is a regulatory mechanism underlying the vulnerability of mitochondria to oxidative injury.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Chen Y,Cai J,Jones DPdoi
10.1016/j.febslet.2006.11.007subject
Has Abstractpub_date
2006-12-11 00:00:00pages
6596-602issue
28-29eissn
0014-5793issn
1873-3468pii
S0014-5793(06)01324-Xjournal_volume
580pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::Transient receptor potential (TRP) proteins are sensory-related cation channels. TRPV subfamily responds to vanilloids, generating a Ca(2+) current. TRPV1, a thermal-sensitive non-selective ion channel, possesses six transmembrane helices and the intracellular N- and C-terminal domains. The latter contains the PIP(2) ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.03.030
更新日期:2012-04-24 00:00:00
abstract::We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are con...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.12.023
更新日期:2006-01-09 00:00:00
abstract::Silent information regulator 2 (Sir2) is an NAD(+)-dependent histone deacetylase that establishes repressive chromatin status and extends the life span of both budding yeast and the nematode worm Caenorhabditis elegans. There is growing evidence that its mammalian homologue Sir2alpha protects cells from stress-induced...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.09.051
更新日期:2006-10-30 00:00:00
abstract::The effects of guanine nucleotides on arachidonic acid (AA) release were studied in intact and saponin-permeabilized human platelets. While GTP[S] itself caused a stimulation of AA release in permeabilized cells, GTP[S], GDP[S], GTP, ATP and other nucleotides inhibited AA release in response to thrombin and other agon...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(88)80107-8
更新日期:1988-07-18 00:00:00
abstract::Motile flagella are crucial for human fertility and embryonic development. The distal tip of the flagellum is where growth and intra-flagellar transport are coordinated. In most model organisms, but not all, the distal tip includes a 'singlet region', where axonemal doublet microtubules (dMT) terminate and only comple...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13379
更新日期:2019-05-01 00:00:00
abstract::Endothelin-1 (ET-1) dose-dependently increased HIF1α expression in pulmonary artery smooth muscle cells (PASMCs). Inhibition of protein synthesis did not affect ET-1-induced HIF1α expression. The maximum effect of ET-1 was similar to that caused by proteasome inhibitor MG132. Further study indicates that ET-1 also dos...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.08.036
更新日期:2012-11-02 00:00:00
abstract::A metallothionein cDNA was generated from pea (Pisum sativum L.) roots, amplified by PCR and inserted into a plasmid for expression in E. coli. Purification of the resultant product generated 3 pools of cadmium-containing material after DEAE-cellulose chromatography. The amino acid composition of each was in excellent...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)81411-z
更新日期:1991-12-16 00:00:00
abstract::The nuclear gene OXA1 was first isolated in Saccharomyces cerevisiae and found to be required at a post-translational step in cytochrome c oxidase biogenesis, probably at the level of assembly. Mutations in OXA1 lead to a complete respiratory deficiency. The protein Oxa1p is conserved through evolution and a human hom...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)00165-2
更新日期:1996-03-11 00:00:00
abstract::Preformed phosphatidylethanolamine-containing liposomes were thiolated with 2-iminothiolane (Traut's reagent) and subsequently activated by mixed disulfide formation with 5,5'-dithiobis(2-nitrobenzoic acid). Up to 65% of amino groups of the outer liposomal lamella, corresponding to 230 SH-groups per vesicle, were modi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)80004-2
更新日期:1987-04-06 00:00:00
abstract::All acetylcholine receptor subunit genes contain E boxes and are blocked by membrane depolarization. We have used transfected C2C12 myogenic cells to investigate the response, to electrical stimulation and KCl, of wildtype and mutant regulatory regions of the chick acetylcholine receptor alpha, gamma and delta subunit...
journal_title:FEBS letters
pub_type: 杂志文章,收录出版
doi:10.1016/0014-5793(95)00496-v
更新日期:1995-06-12 00:00:00
abstract::Adenosine kinase is one of the enzymes potentially responsible for the formation of cytokinin nucleotides in plants. Using a zeatin affinity column a 40 kDa protein was isolated from tobacco Bright Yellow 2 (TBY-2) and identified by mass spectrometry as adenosine kinase. The ligand interaction reported here can be dis...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03750-x
更新日期:2003-01-02 00:00:00
abstract::The binding of phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P(2)) to profilin at a region distinct from the actin interaction surface is demonstrated by experiments with covalently cross-linked profilin:beta-actin. The result is in agreement with observations made with several mutant profilins and provides strong ev...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)02913-7
更新日期:2002-07-03 00:00:00
abstract::Association of protein inclusions or aggregates within brain tissues of patients with neurodegenerative disorders has been widely reported. These inclusions are commonly characterised both by the presence of ubiquitylated proteins and the sequestration of components of the ubiquitin-proteasome system (UPS). Such obser...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2004.12.058
更新日期:2005-01-31 00:00:00
abstract::Southern blotting using a 5'-proximal probe of the Saccharomyces cerevisiae CYR1 gene has revealed heterogeneity in laboratory strains. It is demonstrated that strain AB320 contains a Ty1 element inserted in the promoter region of CYR1. The Ty1 orientation suggests that transcription of CYR1 is initiated downstream fr...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)81227-9
更新日期:1987-07-13 00:00:00
abstract::The dynamics of changes in membrane potential, cytosolic free Ca2+, [Ca2+]i and immunoreactive insulin release were assessed in RINm5F cells. Membrane depolarization and a rise in [Ca2+]i preceded the stimulation of insulin release by D-glyceraldehyde. Forskolin, which raised the cellular cyclic AMP levels, stimulated...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)80972-2
更新日期:1984-11-05 00:00:00
abstract::Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated by dual tyrosine and threonine phosphorylation in vivo. Both MAPKs are phosphorylated and activated in vitro by an activator recently identified as a protein-tyrosine/threonine kinase. We have isolated a putative cDNA for a MAP kinase kinase (MA...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)81481-e
更新日期:1993-02-08 00:00:00
abstract::We studied the molecular mechanism underlying PDT-induced apoptosis-dependent macrophage activation, particularly through NO production. We demonstrate that NO production is initially induced by HSP70 on the apoptotic cell surface, and is further enhanced by macrophage phagocytosis. Additionally, we found that apoptot...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.11.026
更新日期:2013-01-16 00:00:00
abstract::Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. Because reactive oxygen species are believed to play a key role in the development of these diseases, causing cell apoptosis, we investigated whether CsA inhibits H2O2-induc...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00312-9
更新日期:1999-03-26 00:00:00
abstract::Cellular memory is a ubiquitous phenomenon in cell biology. Using numerical simulation and theoretical analysis, we explored the robustness of cellular memory to intrinsic noise in a transcriptional positive feedback system. Without noise, the system could create two stable steady states and function as a memory modul...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2008.10.005
更新日期:2008-11-12 00:00:00
abstract::Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is a highly selective process that can be divided into two steps, receptor-binding followed by translocation through the nuclear envelope. Receptor-binding is mediated by nuclear localization signals that have...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/0014-5793(90)81425-n
更新日期:1990-11-26 00:00:00
abstract::In addition to their g = 1.94 EPR signal, nitrogenase Fe-proteins from Azotobacter vinelandii, Azotobacter chroococcum and Klebsiella pneumoniae exhibit a weak EPR signal with g approximately equal to 5. Temperature dependence of the signal was consistent with an S = 3/2 system with negative zero-field splitting, D = ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(85)81033-4
更新日期:1985-09-23 00:00:00
abstract::TLR3 and TLR4 utilize adaptor TRIF to activate interferon regulatory factor 3 (IRF3), resulting in interferon β (IFN-β) production to mediate anti-viral infection. In this report, we analyzed the effect of two known phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin on LPS- and poly(I:C)-induced I...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.01.016
更新日期:2012-03-23 00:00:00
abstract::Drosophila PTEN (dPTEN) plays indispensable roles in the development of Drosophila melanogaster by controlling cell size and number. Although three potential spliced forms of dPTEN have been isolated, functional distinction among these forms remains elusive. In this study, we demonstrate that all spliced forms of dPTE...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.03.074
更新日期:2004-05-07 00:00:00
abstract::Pheromone receptors are expressed in the accessory olfactory system, which is vital for non-specific chemical communication and for sexual behavior. Under the hypothesis that some of the pheromone molecules released from female reproductive organs might regulate sperm chemotaxis or chemokinesis, we examined whether th...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02411-x
更新日期:2001-01-19 00:00:00
abstract::Acaryochloris marina is a prochlorophyte-like cyanobacterium containing both phycobilins and chlorophyll d as light harvesting pigments. We show that the chlorophyll d light harvesting system, composed of Pcb proteins, functionally associates with the photosystem II (PSII) reaction center (RC) core to form a giant sup...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.01.023
更新日期:2005-02-14 00:00:00
abstract::The ubiquitin-editing enzyme A20 suppresses nuclear factor-κB (NF-κB) activation and tumor necrosis factor-α (TNF-α)-induced apoptosis in a deubiquitinating and ubiquitin ligase activity-dependent manner. Although recent studies revealed that A20 regulates NF-κB independently of its enzymatic activity through its seve...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2015.04.022
更新日期:2015-05-22 00:00:00
abstract::Two hexokinases were characterized in Schizosaccharomyces pombe: hexokinase 1, with a low phosphorylation coefficient on glucose (Km 8.5 mM) and hexokinase 2, a kinetically conventional hexokinase. Genes hxk1+ and hxk2+ encoding these enzymes were cloned and sequenced. Disruption of hxk1+ had no effect on growth but d...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)01451-9
更新日期:1996-01-08 00:00:00
abstract::In plant organelle genomes, homeologous recombination between heteroallelic positions of repetitive sequences is increased by dysfunction of the gene encoding MutS homolog 1 (MSH1), a plant organelle-specific homolog of bacterial mismatch-binding protein MutS1. The C-terminal region of plant MSH1 contains the GIY-YIG ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13279
更新日期:2018-12-01 00:00:00
abstract::Activation of protein kinase C (PKC) in Rat-1 fibroblasts leads to rapid phosphorylation of an 80-kDa protein, a major substrate of PKC. Digitonin-permeabilized cells perfectly supported this early response. Introduction of a PKC pseudosubstrate peptide inhibited 80 kDa phosphorylation with an IC50 of 1 microM, while ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)80657-5
更新日期:1990-02-12 00:00:00
abstract::DNA chip technology was used in an attempt to identify target genes responsible for apoptosis induced by etoposide, a p53 activating topoisomerase II inhibitor used clinically as an antitumor agent. 62 Individual mRNAs whose mass changed significantly were identified after screening oligonucleotide arrays capable of d...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00136-2
更新日期:1999-02-26 00:00:00