Abstract:
:Motile flagella are crucial for human fertility and embryonic development. The distal tip of the flagellum is where growth and intra-flagellar transport are coordinated. In most model organisms, but not all, the distal tip includes a 'singlet region', where axonemal doublet microtubules (dMT) terminate and only complete A-tubules extend as singlet microtubules (sMT) to the tip. How a human flagellar tip is structured is unknown. Here, the flagellar tip structure of human spermatozoa was investigated by cryo-electron tomography, revealing the formation of a complete sMT from both the A-tubule and B-tubule of dMTs. This different tip arrangement in human spermatozoa shows the need to investigate human flagella directly in order to understand their role in health and disease.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zabeo D,Croft JT,Höög JLdoi
10.1002/1873-3468.13379subject
Has Abstractpub_date
2019-05-01 00:00:00pages
892-902issue
9eissn
0014-5793issn
1873-3468journal_volume
593pub_type
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