Abstract:
:Association of protein inclusions or aggregates within brain tissues of patients with neurodegenerative disorders has been widely reported. These inclusions are commonly characterised both by the presence of ubiquitylated proteins and the sequestration of components of the ubiquitin-proteasome system (UPS). Such observations have led to the proposition that the UPS has a direct role in their formation. Indeed, the presence of ubiquitylated proteins and UPS components in inclusions may reflect unsuccessful attempts by the UPS to remove aggregating proteins. Whether the physical presence of inclusions causes cell death or, conversely, whether they are non-toxic and their presence reflects a cellular protective mechanism remains highly controversial.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ardley HC,Hung CC,Robinson PAdoi
10.1016/j.febslet.2004.12.058keywords:
subject
Has Abstractpub_date
2005-01-31 00:00:00pages
571-6issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00014-1journal_volume
579pub_type
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