Abstract:
:Fibroblasts were exposed to various concentrations of hydrogen peroxide and the removal of oxidized proteins was followed by determining protein-bound carbonyls. Fibroblasts are able to increase the turnover of metabolically radiolabeled proteins after treatment with hydrogen peroxide. It was demonstrated for the first time, that the increased protein turnover was accompanied by a removal of protein-bound carbonyl groups. The proteasome-specific inhibitor lactacystin was able to inhibit the elimination of protein-bound carbonyl groups. Therefore, the key role of the proteasome in the degradation of oxidized proteins in fibroblasts could be demonstrated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sitte N,Merker K,Grune Tdoi
10.1016/s0014-5793(98)01495-1subject
Has Abstractpub_date
1998-12-04 00:00:00pages
399-402issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01495-1journal_volume
440pub_type
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