Abstract:
:Anti-cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine-binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine-autoantibody complexes and found that anti-cytokine autoantibody to IL-2, IL-8, tumor necrosis factor-alpha, vascular endothelial growth factor and granulocyte-colony stimulating factor were present in all 15 individuals evaluated, while those to IL-3, osteopontin and macrophage-colony stimulating factor were not detected in anyone. Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Watanabe M,Uchida K,Nakagaki K,Kanazawa H,Trapnell BC,Hoshino Y,Kagamu H,Yoshizawa H,Keicho N,Goto H,Nakata Kdoi
10.1016/j.febslet.2007.04.029subject
Has Abstractpub_date
2007-05-15 00:00:00pages
2017-21issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00417-6journal_volume
581pub_type
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