Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.

abstract：:Rat soleus muscle strips cultured for 24 h in medium 199 were well preserved in terms of electron microscopy; ATP and creatine phosphate concentrations; rates of glucose utilization, glycogen and protein synthesis, and effects of insulin thereon. Culture led to modest changes in fluid spaces and intracellular (K+); in...

journal_title：FEBS letters

authors： Stace PB,Marchington DR,Kerbey AL,Randle PJ

更新日期：1990-10-29 00:00:00

abstract：:Protein deglutathionylation is mainly catalyzed by glutaredoxins (GRXs). We have analyzed the biochemical properties of four of the six different GRXs of Chlamydomonas reinhardtii. Kinetic parameters were determined for disulfide and dehydroascorbate reduction but also for deglutathionylation of artificial and protein...

journal_title：FEBS letters

authors： Gao XH,Zaffagnini M,Bedhomme M,Michelet L,Cassier-Chauvat C,Decottignies P,Lemaire SD

更新日期：2010-06-03 00:00:00

abstract：:We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon (Salmo salar) and Japanese pufferfish (Fugu rubripes), which were termed 'similar to PrPs' (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod ...

journal_title：FEBS letters

authors： Oidtmann B,Simon D,Holtkamp N,Hoffmann R,Baier M

更新日期：2003-03-13 00:00:00

abstract：:Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition t...

journal_title：FEBS letters

authors： Sternberg MJ,Barton GJ,Zvelebil MJ,Cookson J,Coates AR

更新日期：1987-06-29 00:00:00

abstract：:31P-NMR studies of Mycoplasma gallisepticum cells have been carried out using a continuous perfusion technique; these are the first such studies with this organism. Using this technique, glucose metabolism was monitored in the intact organisms, and cell extracts were prepared to identify the intermediates. Under glyco...

journal_title：FEBS letters

authors： Egan W,Barile M,Rottem S

更新日期：1986-08-18 00:00:00

abstract：:In this study, functional proteomics was successfully applied for the characterization of circadian expressed, basic proteins. For this purpose, we have chosen the green model alga Chlamydomonas reinhardtii since its entire nuclear genome is available and it is ideally suited for biochemical enrichment procedures. Pro...

journal_title：FEBS letters

authors： Wagner V,Fiedler M,Markert C,Hippler M,Mittag M

更新日期：2004-02-13 00:00:00

abstract：:Organisms using the thiosulfate-oxidizing Sox enzyme system fall into two groups: group 1 forms sulfur globules as intermediates (Allochromatium vinosum), group 2 does not (Paracoccus pantotrophus). While several components of their Sox systems are quite similar, i.e. the proteins SoxXA, SoxYZ and SoxB, they differ by...

journal_title：FEBS letters

authors： Welte C,Hafner S,Krätzer C,Quentmeier A,Friedrich CG,Dahl C

更新日期：2009-04-17 00:00:00

abstract：:When cultured porcine aortic endothelial cells (ECs) were incubated with porcine big endothelin-1 (bit ET-1(1-39)), there was a time-dependent increase in immunoreactive (IR)-ET in the culture supernatant, in addition to an endogenous IR-ET release fron the cells. Reverse-phase HPLC of the culture supernatant revealed...

journal_title：FEBS letters

authors： Ikegawa R,Matsumura Y,Tsukahara Y,Takaoka M,Morimoto S

更新日期：1991-11-18 00:00:00

abstract：:Proteases not only play a fundamental role in numerous physiological processes, but are also involved in several human diseases including Alzheimer's disease (AD). A key protease implicated in AD is the so far unidentified gamma-secretase, which cleaves the membrane-bound beta-amyloid precursor protein (betaAPP) at th...

journal_title：FEBS letters

authors： Steiner H,Pesold B,Haass C

更新日期：1999-12-17 00:00:00

abstract：:Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly decrea...

journal_title：FEBS letters

authors： Kimura T,Ishikawa K,Sakasegawa Y,Teruya K,Sata T,Schätzl H,Doh-ura K

更新日期：2010-03-19 00:00:00

abstract：:The secretion mechanisms of cathepsin L from osteoclasts in the process of bone resorption were investigated. The increases in bone pit numbers formed take place by PTH addition in parallel with the increases of cathepsin L and/or L-like proteinase activities in the culture medium of bone cells, and these were suppres...

journal_title：FEBS letters

authors： Tagami K,Kakegawa H,Kamioka H,Sumitani K,Kawata T,Lenarcic B,Turk V,Katunuma N

更新日期：1994-04-11 00:00:00

abstract：:The positive strand RNA coronavirus, infectious bronchitis virus (IBV), induces a G2/M phase arrest and reduction in the G1 and G1/S phase transition regulator cyclin D1. Quantitative real-time RT-PCR and Western blot analysis demonstrated that cyclin D1 was reduced post-transcriptionally within infected cells indepen...

journal_title：FEBS letters

authors： Harrison SM,Dove BK,Rothwell L,Kaiser P,Tarpey I,Brooks G,Hiscox JA

更新日期：2007-04-03 00:00:00

abstract：:Acute hyperammonemia, induced by two consecutive injections of ammonium acetate (550 and 450 mg per kg b.wt.), decreased the activity of gamma-glutamyl transpeptidase (GGT) in most brain regions of 18- and 30-day-old rats. This decrease in the brain GGT activity was more pronounced in younger than in older rats. After...

journal_title：FEBS letters

authors： Stastný F,Pitha J,Lisý V,Hilgier W,Kaucká I,Albrecht J

更新日期：1992-04-06 00:00:00

abstract：:A cDNA encoding stromal ascorbate peroxidase (sAPX) was isolated using poly(A)+ RNA of pumpkin cotyledons by RT-PCR. The cDNA encodes a polypeptide with 372 amino acids and shares complete sequence identity with pumpkin thylakoid-bound ascorbate peroxidase (tAPX), except for the deletion of a putative membrane spannin...

journal_title：FEBS letters

authors： Mano S,Yamaguchi K,Hayashi M,Nishimura M

更新日期：1997-08-11 00:00:00

abstract：:The formation of cytoplasmic inclusion bodies by Escherichia coli overproducing Clostridium thermocellum endoglucanase D (EGD) was investigated. EGD was found in inclusion bodies as a 68 kDa form, whereas the size of the cytoplasmic form was 65 kDa. Upon solubilization with urea followed by dialysis, the 68 kDa form w...

journal_title：FEBS letters

authors： Tokatlidis K,Dhurjati P,Millet J,Béguin P,Aubert JP

更新日期：1991-04-22 00:00:00

abstract：:Studies were designed to elucidate the mechanism by which unsaturated fatty acids inhibit the binding of triiodothyronine (T3) ro rat liver nuclei. The possibility of a direct interaction between oleic acid and T3 was excluded by dialysis experiments. Oleic acid inhibits nuclear T3 binding in a strictly competitive ma...

journal_title：FEBS letters

authors： van der Klis FR,Wiersinga WM,de Vijlder JJ

更新日期：1989-03-27 00:00:00

abstract：:We previously showed that the post-translational cleavage of alphav subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking alphav subunit cleavage by expression of alpha1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of t...

journal_title：FEBS letters

authors： Berthet V,Rigot V,Nejjari M,Marvaldi J,Luis J

更新日期：2004-01-16 00:00:00

abstract：:The stimulatory effects of several DNA-binding basic proteins (histone and protamine) and HIV-1 Rev with arginine (Arg)-rich clusters on the activity of casein kinase II (CK-II) were investigated in vitro. It was found that recombinant Rev (rRev) and the synthetic oligo-fragments corresponding to the amino acid sequen...

journal_title：FEBS letters

authors： Ohtsuki K,Maekawa T,Harada S,Karino A,Morikawa Y,Ito M

更新日期：1998-05-29 00:00:00

abstract：:We analysed the biochemical properties of insulin receptors of a Type A insulin resistant patient with a single heterozygous point mutation substituting Gln for Arg1174. Insulin binding capacity and affinity to Epstein-Barr virus transformed lymphocytes was normal. Quantitative analysis of autophosphorylation and subs...

journal_title：FEBS letters

authors： Moritz W,Froesch ER,Böni-Schnetzler M

更新日期：1994-09-05 00:00:00

abstract：:The fibronectin type II (FnII) domain, present in diverse vertebrate proteins, plays crucial roles in several fundamental biological processes. PDC-109, the major bovine seminal plasma protein, contains two FnII domains that bind to choline phospholipids on sperm plasma membrane and induce lipid efflux crucial for suc...

journal_title：FEBS letters

authors： Singh BP,Asthana A,Basu A,Tangirala R,Mohan Rao C,Swamy MJ

更新日期：2020-02-01 00:00:00

abstract：:Like glutathione or dithiothreitol, metallothionein effects the formation of pancreatic ribonuclease A from its S-sulfonated derivative catalyzed by protein disulfide isomerase. EDTA increases the yield of ribonuclease A activity recovery with metallothionein but does not affect the reaction with glutathione or dithio...

journal_title：FEBS letters

authors： Zhang S,Li J,Wang CC,Tsou CL

更新日期：1999-12-03 00:00:00

abstract：:In fission yeast, the only known essential function of Ned8p is the modification of the cullin, Pcu1p, and subsequent Cullin-RING-Ligase (CRL) activation and substrate ubiquitination. We show here that a functional Pcu1p mutant, deleted for its C-terminal autoinhibitory domain, which negates the requirement of neddyla...

journal_title：FEBS letters

authors： Girdwood D,Robertson M,Gordon C

更新日期：2012-05-21 00:00:00

abstract：:Iron regulatory protein 2 (IRP2) is a critical switch for cellular and systemic iron homeostasis. In iron-deficient or hypoxic cells, IRP2 binds to mRNAs containing iron responsive elements (IREs) and regulates their expression. Iron promotes proteasomal degradation of IRP2 via the F-box protein FBXL5. Here, we explor...

journal_title：FEBS letters

authors： Hausmann A,Lee J,Pantopoulos K

更新日期：2011-02-18 00:00:00

abstract：:MeCP2 is a chromatin-associated protein that is mutated in Rett syndrome. Its methyl-CpG-binding domain interacts with DNA containing methylated cytosine, but other modes of recruitment to the genome have also been proposed. Here, we use in vitro and in vivo assays to investigate the DNA binding specificity of two AT-...

journal_title：FEBS letters

authors： Lyst MJ,Connelly J,Merusi C,Bird A

更新日期：2016-09-01 00:00:00

abstract：:The transcription factor Pdr1p recognizes Pdr1p/Pdr3p-response element (PDRE) to activate genes involved in multidrug resistance of the budding yeast. To identify novel targets of Pdr1p, we compared transcriptomes among the yeast cells bearing wild, disrupted and gain-of-function alleles of PDR1 using a high-throughpu...

journal_title：FEBS letters

authors： Miura F,Yada T,Nakai K,Sakaki Y,Ito T

更新日期：2001-09-07 00:00:00

abstract：:Cytotoxic effects were observed following 4 h incubation of human leukaemic cells with the iron chelator 1-hydroxypyridine-2-thione (omadine). Its cytotoxic activity was comparable to that of the cytotoxic drug doxorubicin. At the same concentration two other effective iron chelators, desferrioxamine and 1,2-dimethyl-...

journal_title：FEBS letters

authors： Kontoghiorghes GJ,Piga A,Hoffbrand AV

更新日期：1986-08-18 00:00:00

abstract：:The involvement of Ca(2+) in the response to high Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), and Hg(2+) was investigated in Saccharomyces cerevisiae. The yeast cells responded through a sharp increase in cytosolic Ca(2+) when exposed to Cd(2+), and to a lesser extent to Cu(2+), but not to Mn(2+), Co(2+), Ni(2+), ...

journal_title：FEBS letters

authors： Ruta LL,Popa VC,Nicolau I,Danet AF,Iordache V,Neagoe AD,Farcasanu IC

更新日期：2014-08-25 00:00:00

abstract：:The chloroplast signal recognition particle (cpSRP) consists of a conserved 54 kDa subunit (cpSRP54) and a unique 43 kDa subunit (cpSRP43) but lacks SRP-RNA, an essential and universally conserved component of cytosolic SRPs. High sequence similarity exists between cpSRP54 and bacterial SRP54 except for a plant-specif...

journal_title：FEBS letters

authors： Richter CV,Träger C,Schünemann D

更新日期：2008-09-22 00:00:00

abstract：:Peptide T, an octapeptide of sequence ASTTTNYT that binds to human T cells, was studied as a zwitterion in DMSOd6 solution by means of proton NMR spectroscopy at 500 MHz. The unusual dispersion of the resonances of residues of the same type (T) makes it possible to assign all resonances to specific residues by means o...

journal_title：FEBS letters

authors： Picone D,Temussi PA,Marastoni M,Tomatis R,Motta A

更新日期：1988-04-11 00:00:00

abstract：:To explore the structural basis required for the holoenzyme formation of cAMP-dependent protein kinase, we have prepared rabbit anti-peptide antibodies that can block the holoenzyme formation without affecting the catalytic activity of the enzyme. The antibodies were raised against a specific site in the catalytic (C)...

journal_title：FEBS letters

authors： Sahara S,Sato K,Kaise H,Mori K,Sato A,Aoto M,Tokmakov AA,Fukami Y

更新日期：1996-04-15 00:00:00