Abstract:
:Studies were designed to elucidate the mechanism by which unsaturated fatty acids inhibit the binding of triiodothyronine (T3) ro rat liver nuclei. The possibility of a direct interaction between oleic acid and T3 was excluded by dialysis experiments. Oleic acid inhibits nuclear T3 binding in a strictly competitive manner. The Ki value of oleic acid was approx. 10(4) times greater than that of T3. The inhibitory effect of oleic acid could be reversed by bovine serum albumin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
van der Klis FR,Wiersinga WM,de Vijlder JJdoi
10.1016/0014-5793(89)80242-xsubject
Has Abstractpub_date
1989-03-27 00:00:00pages
6-12issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80242-Xjournal_volume
246pub_type
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