Abstract:
:Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-kappaB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-kappaB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Santos SC,Monni R,Bouchaert I,Bernard O,Gisselbrecht S,Gouilleux F,Penard-Lacronique Vdoi
10.1016/s0014-5793(01)02452-8keywords:
subject
Has Abstractpub_date
2001-05-25 00:00:00pages
148-52issue
2-3eissn
0014-5793issn
1873-3468pii
S0014579301024528journal_volume
497pub_type
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