Abstract:
:The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sachinidis A,Weisser P,Ko Y,Schulte K,Meyer zu Brickwedde K,Neyses L,Vetter Hdoi
10.1016/0014-5793(92)81423-jkeywords:
subject
Has Abstractpub_date
1992-11-23 00:00:00pages
109-12issue
2eissn
0014-5793issn
1873-3468journal_volume
313pub_type
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