Abstract:
:Streptozotocin (STZ)-induced diabetic animals are vulnerable to cold stress. Uncoupling proteins (UCPs) play an important role in regulating thermogenesis. We investigated the gene expressions of UCPs in brown adipose tissue (BAT), white adipose tissue (WAT), liver and gastrocnemius muscle of STZ-diabetic rats using Northern blot. UCP-1, -2 and -3 mRNA expressions in BAT were all remarkably lower in STZ-diabetic rats than those in control rats. Both UCP-2 and -3 gene expressions in gastrocnemius muscle were substantially elevated in STZ-diabetic rats and insulin treatment restored UCP gene expressions to normal levels. These results suggest that in STZ-diabetic rats, the overexpression of UCP-2 and UCP-3 in skeletal muscle provides a defense against hypothermogenesis caused by decreased UCPs in BAT.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kageyama H,Suga A,Kashiba M,Oka J,Osaka T,Kashiwa T,Hirano T,Nemoto K,Namba Y,Ricquier D,Giacobino JP,Inoue Sdoi
10.1016/s0014-5793(98)01506-3subject
Has Abstractpub_date
1998-12-04 00:00:00pages
450-3issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01506-3journal_volume
440pub_type
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