Abstract:
:α-Synuclein (αSyn) is a key player in the pathogenesis of Parkinson's disease and other synucleinopathies. Here, we report the existence of a novel soluble α-helical conformer of αSyn, obtained through transient interaction with lipid interfaces, and propose dynamic oligomerization as the mechanism underlying its stability. The conformational space of αSyn appears to be highly context-dependent, and lipid bilayers might thus play crucial roles as molecular chaperones in a cellular environment.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rovere M,Sanderson JB,Fonseca-Ornelas L,Patel DS,Bartels Tdoi
10.1002/1873-3468.13047subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1464-1472issue
9eissn
0014-5793issn
1873-3468journal_volume
592pub_type
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