Abstract:
:The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although semaphorins were originally identified as guidance cues in neural development, accumulating evidence indicates that several semaphorins called 'immune semaphorins', such as Sema3A, 4A, 4D, 6D and 7A, are critically involved in various phases of the immune response by regulating immune cell-cell contacts or cell migration. In this review, we present recent knowledge on the functions of semaphorins and their receptors in the immune system and their potential roles in the pathogenesis of multiple sclerosis (MS), a representative CNS autoimmune disease, and its animal model, experimental autoimmune encephalomyelitis (EAE).
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Okuno T,Nakatsuji Y,Kumanogoh Adoi
10.1016/j.febslet.2011.03.033subject
Has Abstractpub_date
2011-12-01 00:00:00pages
3829-35issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00196-7journal_volume
585pub_type
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