Abstract:
:MicroRNAs (miRNA) play an important role in tumorigenesis, proliferation, and differentiation. Altered miRNA expression in cancer indicates that miRNAs can function as tumor suppressors or oncogenes. MiR-449c downregulation in non-small cell lung cancer (NSCLC) compared with normal lung tissues was investigated in this study. NSCLC cell proliferation and invasion assays indicate that transfection of miR-449c expression plasmid inhibits the proliferation and invasion ability of NCI-H23 and NCI-H838 cells. In addition, miR-449c overexpression could suppress tumor growth in vivo. Morever, c-Myc was identified as a direct target gene of miR-449c. These findings clearly suggest that miR-449c downregulation and c-Myc amplification may be involved in the development of NSCLC.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miao LJ,Huang SF,Sun ZT,Gao ZY,Zhang RX,Liu Y,Wang Jdoi
10.1016/j.febslet.2013.03.006subject
Has Abstractpub_date
2013-05-02 00:00:00pages
1359-65issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00204-4journal_volume
587pub_type
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