FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

abstract：:The enzyme telomerase is necessary for the synthesis and maintenance of telomere length. The catalytic subunit, telomerase reverse transcriptase (TERT), is regulated by interaction with the 90 kDa heat shock protein (HSP90) and by Akt-dependent phosphorylation. Here, we demonstrate that HSP90 and Akt physically intera...

journal_title：FEBS letters

authors： Haendeler J,Hoffmann J,Rahman S,Zeiher AM,Dimmeler S

更新日期：2003-02-11 00:00:00

abstract：:We analysed the biochemical properties of insulin receptors of a Type A insulin resistant patient with a single heterozygous point mutation substituting Gln for Arg1174. Insulin binding capacity and affinity to Epstein-Barr virus transformed lymphocytes was normal. Quantitative analysis of autophosphorylation and subs...

journal_title：FEBS letters

authors： Moritz W,Froesch ER,Böni-Schnetzler M

更新日期：1994-09-05 00:00:00

abstract：:DNA is very stable in its double-stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single-stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nuc...

journal_title：FEBS letters

authors： Thömmes P,Hübscher U

更新日期：1990-08-01 00:00:00

abstract：:The impact of hexose-6-phosphate dehydrogenase (H6PDH) on 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 activity was investigated upon coexpression in HEK-293 cells. Confocal microscopy analysis indicated colocalisation of both enzymes at the lumenal side of the endoplasmic reticulum (ER) membrane. Functiona...

journal_title：FEBS letters

authors： Atanasov AG,Nashev LG,Schweizer RA,Frick C,Odermatt A

更新日期：2004-07-30 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated by dual tyrosine and threonine phosphorylation in vivo. Both MAPKs are phosphorylated and activated in vitro by an activator recently identified as a protein-tyrosine/threonine kinase. We have isolated a putative cDNA for a MAP kinase kinase (MA...

journal_title：FEBS letters

authors： Haystead CM,Wu J,Gregory P,Sturgill TW,Haystead TA

更新日期：1993-02-08 00:00:00

abstract：:Caveolin is a protein present in membrane specializations termed caveolae where it may play a structural role. Previous studies on the cDNA sequence of chicken caveolin demonstrated that it is an integral membrane protein without significant homology to any known protein. The cDNA sequence of human lung caveolin is pr...

journal_title：FEBS letters

authors： Glenney JR Jr

更新日期：1992-12-07 00:00:00

abstract：:To determine the amino acid residues required for the signal-transducing activity of the human c-Ha-Ras protein, we introduced point mutations at residues 45-54 near the 'effector region' (residues 32-40). We transfected PC12 cells with these mutant genes and also micro-injected the mutant proteins, bound with an unhy...

journal_title：FEBS letters

authors： Fujita-Yoshigaki J,Shirouzu M,Koide H,Nishimura S,Yokoyama S

更新日期：1991-12-09 00:00:00

abstract：:The role of the Ca(2+)-activated tyrosine kinase, Pyk2, in the pleiotropic coupling of nerve cell stimulation to the MAP kinase cascade still remains undefined. Using a panel of PC12 clones, one of which was defective in Pyk2, we demonstrate (1) that the MAP kinase response induced by a [Ca(2+)](i) rise (following app...

journal_title：FEBS letters

authors： Barsacchi R,Heider H,Girault J,Meldolesi J

更新日期：1999-11-19 00:00:00

abstract：:The sarcoplasmic reticulum-bound creatine kinase from rabbit skeletal muscle was inhibited by the nitric oxide donor S-nitrosoglutathione (GSNO). This led to a decrease in Ca2+ uptake in sarcoplasmic reticulum vesicles when the transport was driven by ATP generated from phosphocreatine and ADP. In contrast, the Ca 2+ ...

journal_title：FEBS letters

authors： Wolosker H,Panizzutti R,Engelender S

更新日期：1996-09-02 00:00:00

abstract：:The C1 domains are 50 amino acid sequences present in protein kinase C (PKC) isozymes that are responsible for binding of phorbol esters and the lipid second messenger diacylglycerol (DAG). We found that bacterially expressed C1b domain of PKCdelta induces germinal vesicle breakdown (GVBD) when microinjected into Xeno...

journal_title：FEBS letters

authors： Aroca P,Santos E,Kazanietz MG

更新日期：2000-10-13 00:00:00

abstract：:Natural freeze tolerance depends on cellular adaptations that address the multiple stresses imposed on cells during freezing. These adaptations preserve viability by suppressing energy-expensive cell processes in the frozen state. In this study, we explore the freeze-responsive expression of microRNA in hatchling pain...

journal_title：FEBS letters

authors： Biggar KK,Storey KB

更新日期：2015-11-30 00:00:00

abstract：:As an attempt to investigate the dynamic interactions between plasma serine protease, coagulation factor VIIa (VIIa) and its cofactor, tissue factor (TF), we performed normal mode analysis (NMA) of the complex of VIIa with soluble TF (the extracellular part of TF; sTF). We compared fluctuations of Calpha atoms of VIIa...

journal_title：FEBS letters

authors： Soejima K,Kurihara Y,Kamiya K,Umeyama H

更新日期：1999-12-10 00:00:00

abstract：:Amino acid sequencing of a 48/46 kDa glycoprotein from human plantar callus, recognised by antisera raised against the desmosomal cadherins DGII/III, has revealed N-terminal homology to the DNA-derived sequence of human and bovine DGII/III. However, a tryptic fragment has homology only with a bovine clone. We propose ...

journal_title：FEBS letters

authors： King IA,Magee AI,Rees DA,Buxton RS

更新日期：1991-07-29 00:00:00

abstract：:A cDNA of a novel form of type V adenylyl cyclase has been cloned from rabbit myocardium using oligonucleotide probes derived from peptides that were produced by enzymatic cleavage of purified heart cyclase. A corresponding mRNA (6 kb) has been detected in rabbit myocardial tissue by Northern blot analysis. The cDNA e...

journal_title：FEBS letters

authors： Wallach J,Droste M,Kluxen FW,Pfeuffer T,Frank R

更新日期：1994-02-07 00:00:00

abstract：:The chloroplast inner envelope translocon subunit Tic110 is imported via a soluble stromal translocation intermediate. In this study an in-organellar import system is established which allows for an accumulation of this intermediate in order to analyze its requirements for reexport. All results demonstrate that the re...

journal_title：FEBS letters

authors： Vojta L,Soll J,Bölter B

更新日期：2007-06-12 00:00:00

abstract：:The success of Cre-mediated conditional gene targeting in liver of mice has until now depended on the generation of Cre recombinase transgenic mice or on viral-mediated transduction. Here, we sought to establish the feasibility of using hydrodynamic gene delivery of Cre recombinase into liver, using a ROSA26 EGFP mous...

journal_title：FEBS letters

authors： Zhu HZ,Wang W,Feng DM,Sai Y,Xue JL

更新日期：2006-08-07 00:00:00

abstract：:A novel structural classification of beta proteins is presented from the viewpoint of the ring-shaped structure and the zipper-like contact pattern, based on the fact that 92% and 60% of beta proteins have the ring topology and the zippered contact pattern, respectively. We discuss the implication of the unexpectedly ...

journal_title：FEBS letters

authors： Koike R,Kinoshita K,Kidera A

更新日期：2003-01-02 00:00:00

abstract：:Tyrosine-rich acidic matrix protein (TRAMP; 22 kDa extracellular matrix protein; dermatopontin) is a protein that co-purifies with lysyl oxidase and with dermatan sulphate proteoglycans, with possible functions in cell-matrix interactions and matrix assembly. Using a rabbit polyclonal antiserum raised against porcine ...

journal_title：FEBS letters

authors： Forbes EG,Cronshaw AD,MacBeath JR,Hulmes DJ

更新日期：1994-09-12 00:00:00

abstract：:On the basis of recent results, we propose a model for DNA polymerase translocation along DNA. Human immunodeficiency virus reverse transcriptase is taken as an example. According to the model, movement of the enzyme is the result of transition of the enzyme-bound DNA from the A- to B-form which is accompanied by leng...

journal_title：FEBS letters

authors： Wlassoff WA,Dymshits GM,Lavrik OI

更新日期：1996-07-15 00:00:00

abstract：:L-selectin guides lymphocytes into peripheral lymphoid tissues by recognizing glycoprotein ligands decorated with 6-sulfated sialyl Lewis x (sulfo sLex). Here we have used a rat peripheral lymph node high endothelial cell line (Ax) to study in detail the synthesis, expression and degradation of sLex epitope. We show h...

journal_title：FEBS letters

authors： Majuri ML,Räbinä J,Niittymäki J,Tiisala S,Mattila P,Aavik E,Miyasaka M,Renkonen O,Renkonen R

更新日期：1999-07-16 00:00:00

abstract：:An electrometric technique was used to investigate electron transfer between spinach plastocyanin (Pc) and photooxidized primary electron donor P700 in photosystem I (PS I) complexes from the cyanobacterium Synechocystis sp. PCC 6803. In the presence of Pc, the fast unresolvable kinetic phase of membrane potential gen...

journal_title：FEBS letters

authors： Mamedov MD,Mamedova AA,Chamorovsky SK,Semenov AY

更新日期：2001-07-06 00:00:00

abstract：:Here we summarize evidence for non-equivalence of two structurally similar active sites in transketolase and other thiamine-dependent enzymes. This non-equivalence takes place when the enzymes interact with various ligands (inhibitors, cations, coenzyme and substrates). Data on different strains in the structure of th...

journal_title：FEBS letters

authors： Kovina MV,Kochetov GA

更新日期：1998-11-27 00:00:00

abstract：:Studies were designed to elucidate the mechanism by which unsaturated fatty acids inhibit the binding of triiodothyronine (T3) ro rat liver nuclei. The possibility of a direct interaction between oleic acid and T3 was excluded by dialysis experiments. Oleic acid inhibits nuclear T3 binding in a strictly competitive ma...

journal_title：FEBS letters

authors： van der Klis FR,Wiersinga WM,de Vijlder JJ

更新日期：1989-03-27 00:00:00

abstract：:Rats bearing the fast-growing AH-130 Yoshida ascites hepatoma showed a marked cachectic response which has been previously reported [Tessitore et al. (1987) Biochem. J. 241, 153-159]. Thus tumour-bearing animals showed significant decreases in body and muscle weight (soleus and gastrocnemius) as compared to both pair-...

journal_title：FEBS letters

authors： Llovera M,García-Martínez C,Agell N,Marzábal M,López-Soriano FJ,Argilés JM

更新日期：1994-02-07 00:00:00

abstract：:Human Bfl-1 is an anti-apoptotic Bcl-2 family member. Here, we found that Bfl-1 was converted into a potent death-promoting protein by green fluorescent protein (GFP) fusion with its N-terminus. The transient expression of GFP-Bfl-1 induced cytochrome c release and triggered apoptosis in 293T cells, which depended on ...

journal_title：FEBS letters

authors： Ko JK,Choi KH,Kim HJ,Choi HY,Yeo DJ,Park SO,Yang WS,Kim YN,Kim CW

更新日期：2003-09-11 00:00:00

abstract：:The type 1 ribosome-inactivating protein (RIP) saporin 5 isolated from seeds of Saponaria officinalis L. strongly inhibited translation carried out by Vicia sativa L. purified ribosomes. The toxin multidepurinated V. sativa rRNA, which upon treatment with acid aniline releases several RNA fragments including an RNA fr...

journal_title：FEBS letters

authors： Iglesias R,Arias FJ,Rojo MA,Escarmis C,Ferreras JM,Girbés T

更新日期：1993-07-05 00:00:00

abstract：:Parkinson's disease is the second most common neurodegenerative disease, and results from loss of dopaminergic neurons in the substantia nigra. The aggregation and fibrillation of alpha-synuclein in the form of intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) have been implicated as a causative f...

journal_title：FEBS letters

authors： Uversky VN,Fink AL

更新日期：2002-07-03 00:00:00

abstract：:Activation of protein kinase C (PKC) in Rat-1 fibroblasts leads to rapid phosphorylation of an 80-kDa protein, a major substrate of PKC. Digitonin-permeabilized cells perfectly supported this early response. Introduction of a PKC pseudosubstrate peptide inhibited 80 kDa phosphorylation with an IC50 of 1 microM, while ...

journal_title：FEBS letters

authors： Eichholtz T,Alblas J,van Overveld M,Moolenaar W,Ploegh H

更新日期：1990-02-12 00:00:00

abstract：:Interleukin-4 (IL-4) is a pleiotropic cytokine, which acts on both hematopoietic and non-hematopoietic cells, through different types of receptor complexes. In this study, we report that in human B cells, IL-4 caused rapid phosphorylation of Janus kinase (JAK) 1 and JAK3 tyrosine kinases. In keratinocytes, the hematop...

journal_title：FEBS letters

authors： Wery-Zennaro S,Letourneur M,David M,Bertoglio J,Pierre J

更新日期：1999-12-24 00:00:00

abstract：:The specific binding of [3H]retinoids to cellular retinoid-binding proteins was measured directly by the cold acetone filtration method. After incubation of purified cellular retinoid-binding proteins with [3H]retinoids with or without competitors for 2-4 h, bound ligands were separated from free by filtration using c...

journal_title：FEBS letters

authors： Ninomiya M,Suganuma M,Paik NS,Muto Y,Fujiki H

更新日期：1988-06-20 00:00:00