Zinc transporters maintain longevity by influencing insulin/IGF-1 activity in Caenorhabditis elegans.

abstract：:Na+ transport through the F0 domain of Na(+)-F1F0-ATPases involves the combined action of subunits c and a but the residues involved in Na+ liganding in subunit a are unknown. As a first step towards the identification of these residues, we have cloned and sequenced the gene encoding subunit a of the Na(+)-F1F0-ATPase...

journal_title：FEBS letters

authors： Rahlfs S,Müller V

更新日期：1999-06-18 00:00:00

abstract：:Two protein phosphatases of 103 and 29 kDa as determined by gel filtration, were purified from hen oviducts. The 103 -kDa phosphatase was purified 7300-fold to near homogeneity and dissociated into two polypeptides in the presence of SDS. Molecular masses of these polypeptides were estimated to be 60 and 38 kDa by SDS...

journal_title：FEBS letters

authors： Kanayama K,Wada K,Negami A,Yamamura H,Tanabe T

更新日期：1985-05-06 00:00:00

abstract：:The multidrug resistance protein (MRP) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we report that dinitrophenyl-S-glutathione increases ATPase activity in plasma membrane vesicles prepared from the MRP-overexpressing cell line GLC4...

journal_title：FEBS letters

authors： Hooijberg JH,Broxterman HJ,Heijn M,Fles DL,Lankelma J,Pinedo HM

更新日期：1997-08-18 00:00:00

abstract：:A homogenate of purified chromaffin cells was fractionated, after removal of the nuclear fraction, by sucrose density gradient ultracentrifugation. The presence and subcellular localization of low molecular mass GTP-binding proteins was explored by incubation of blots of proteins from different subcellular fractions w...

journal_title：FEBS letters

authors： Doucet JP,Fournier S,Parulekar M,Trifaró JM

更新日期：1989-04-10 00:00:00

abstract：:Rapidly generated high-titer Semliki Forest virus (SFV) vectors can infect numerous mammalian cell lines and primary cell cultures, and result in high levels of transgene expression. SFV-based expression of transmembrane receptors has been characterized by specific ligand-binding activity and functional responses. Ada...

journal_title：FEBS letters

authors： Lundstrom K,Schweitzer C,Rotmann D,Hermann D,Schneider EM,Ehrengruber MU

更新日期：2001-08-31 00:00:00

abstract：:The number of proteins found in body fluids and at cell surfaces, which are known to display carbohydrate-binding properties, continues to increase rapidly. In these proteins, in addition to a domain associated with lectin properties, one or more, non-lectin domains are present. It is possible that binding of sugar re...

journal_title：FEBS letters

authors： Thiel S,Reid KB

更新日期：1989-06-19 00:00:00

abstract：:The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle...

journal_title：FEBS letters

authors： White R,Morganstein D,Christian M,Seth A,Herzog B,Parker MG

更新日期：2008-01-09 00:00:00

abstract：:PA28, a 200 kDa activator of 20S proteasomes, was purified from human placenta and was gel electrophoretically resolved into two different subunits, alpha and beta. In reconstitution experiments, alpha-subunits alone were found to re-associate forming homooligomers with an M(r) of about 200 kDa, which elicit a stimula...

journal_title：FEBS letters

authors： Kuehn L,Dahlmann B

更新日期：1996-09-30 00:00:00

abstract：:The possibility that the phospholipid-N-methyltransferases from yeast are capable of acting upon a phospholipid substrate, localized in a different membrane than in which the enzymes reside ('trans-catalysis' hypothesis), was investigated using cho2 and opi3 gene disruptant strains, which are defective in phosphatidyl...

journal_title：FEBS letters

authors： Janssen MJ,de Jong HM,de Kruijff B,de Kroon AI

更新日期：2002-02-27 00:00:00

abstract：:Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed. Clathrin-dependent e...

journal_title：FEBS letters

authors： Buechler C,Wanninger J,Neumeier M

更新日期：2010-10-22 00:00:00

abstract：:The effects of guanine nucleotides on arachidonic acid (AA) release were studied in intact and saponin-permeabilized human platelets. While GTP[S] itself caused a stimulation of AA release in permeabilized cells, GTP[S], GDP[S], GTP, ATP and other nucleotides inhibited AA release in response to thrombin and other agon...

journal_title：FEBS letters

authors： Rehm AG,Wu H,Halenda SP

更新日期：1988-07-18 00:00:00

abstract：:Transient receptor potential (TRP) proteins are sensory-related cation channels. TRPV subfamily responds to vanilloids, generating a Ca(2+) current. TRPV1, a thermal-sensitive non-selective ion channel, possesses six transmembrane helices and the intracellular N- and C-terminal domains. The latter contains the PIP(2) ...

journal_title：FEBS letters

authors： Aguado-Llera D,Bacarizo J,Gregorio-Teruel L,Taberner FJ,Cámara-Artigas A,Neira JL

更新日期：2012-04-24 00:00:00

abstract：:α-Glucosidase hydrolyzes α-glucosides and transfers α-glucosyl residues to an acceptor through transglucosylation. In this study, GH13_31 α-glucosidase BspAG13_31A with high transglucosylation activity is reported in Bacillus sp. AHU2216 and biochemically and structurally characterized. This enzyme is specific to α-(1...

journal_title：FEBS letters

authors： Auiewiriyanukul W,Saburi W,Kato K,Yao M,Mori H

更新日期：2018-07-01 00:00:00

abstract：:The covalent structure and most of the stereochemistry of the pseudomycins, bioactive metabolites of a transposon-generated mutant of a Pseudomonas syringae wild-type strain proposed for the biological control of Dutch elm disease, have been determined. While two pseudomycins are identical to the known syringopeptins ...

journal_title：FEBS letters

authors： Ballio A,Bossa F,Di Giorgio D,Ferranti P,Paci M,Pucci P,Scaloni A,Segre A,Strobel GA

更新日期：1994-11-21 00:00:00

abstract：:A comparison is made between the PQA----P+QA- and PQAQB----P+QAQB-transitions in Rps. viridis and Rb. sphaeroides reaction centers (RCs) by the use of light-induced Fourier transform infrared (FTIR) difference spectroscopy. In Rb. sphaeroides RCs, we identify a signal at 1650 cm-1 which is present in the P+QA-minus-PQ...

journal_title：FEBS letters

authors： Nabedryk E,Bagley KA,Thibodeau DL,Bauscher M,Mäntele W,Breton J

更新日期：1990-06-18 00:00:00

abstract：:Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K(+) channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic effects of RGSs on GIRK regulation. At low concentrations, RGS4 inhibited basal GIRK activity, but stimulated it at high c...

journal_title：FEBS letters

authors： Keren-Raifman T,Bera AK,Zveig D,Peleg S,Witherow DS,Slepak VZ,Dascal N

更新日期：2001-03-09 00:00:00

abstract：:In this study, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) induced an increase in the cell viability of the androgen-responsive prostate cancer LNCaP cells, which was reversed by the use of the TRPV1 antagonists capsazepine, I-RTX and SB 366791. In further studies we observed that capsaicin induced a decrease i...

journal_title：FEBS letters

authors： Malagarie-Cazenave S,Olea-Herrero N,Vara D,Díaz-Laviada I

更新日期：2009-01-05 00:00:00

abstract：:We found that, in the presence of chimeric oligonucleotides containing complementary deoxyribo- and 2'-O-methylnucleosides, a nonaribonucleotide, [5'-32P]pACUUACCUG, was cleaved specifically upon treatment with RNase H. When 3'm(UG)d(AATG)m(GAC)5' was used as a hybridization strand, pACUUACCUG was cleaved between C6 a...

journal_title：FEBS letters

authors： Inoue H,Hayase Y,Iwai S,Ohtsuka E

更新日期：1987-05-11 00:00:00

abstract：:Mitochondrial translocation of ceramides triggers Bax-dependent apoptosis. To elucidate how ceramides activate Bax and commit cells to death, we developed a switchable version of the ceramide transfer protein CERT, sCERT. Upon its drug-induced recruitment to mitochondria, sCERT retains the ability to bind VAP proteins...

journal_title：FEBS letters

authors： Jain A,Dadsena S,Holthuis JCM

更新日期：2020-11-01 00:00:00

abstract：:Lipids are essential eukaryotic cellular constituents. Lipid metabolism has a strong impact on cell physiology, and despite good progress in this area, many important basic questions remain unanswered concerning the functional diversity of lipid species and on the mechanisms that cells employ to sense and adjust their...

journal_title：FEBS letters

authors： Santos AX,Riezman H

更新日期：2012-08-31 00:00:00

abstract：:LncRNAs have a critical role in the regulation of cellular processes such as cancer progression and metastasis. In the present study, we confirmed that TUG1 was overexpressed in bladder cancer tissues and established cell lines. Knockdown of TUG1 inhibited bladder cancer cell metastasis both in vitro and in vivo. Furt...

journal_title：FEBS letters

authors： Tan J,Qiu K,Li M,Liang Y

更新日期：2015-10-07 00:00:00

abstract：:Acceptor stem variants of tRNA(fMet) (Escherichia coli) have been characterized by nuclear magnetic resonance. The wild type contains a C1-A72 mismatch pair which is crucial for its biological function. For comparison, the mismatch was replaced by regular pairs U1-A72 and C1-G72. Further variants contain an altered di...

journal_title：FEBS letters

authors： Zuleeg T,Vogtherr M,Schübel H,Limmer S

更新日期：2000-04-28 00:00:00

abstract：:We report here the apoptosis of mouse liver nuclei induced in the cytosol of carrot cells by cytochrome c. Several typical characteristics of apoptosis, such as chromatin condensation, margination and apoptotic bodies, were detected. The result of DNA gel electrophoresis showed that DNA was degraded into nucleosomal f...

journal_title：FEBS letters

authors： Zhao Y,Jiang ZF,Sun YL,Zhai ZH

更新日期：1999-04-01 00:00:00

abstract：:Physiological amyloid aggregation occurs within the nuclei of stress-treated cells. These structures, termed Amyloid bodies (A-bodies), assemble through the rapid accumulation of proteins into dense membrane-less organelles, which possess the same biophysical properties as plaques observed in many amyloid-based diseas...

journal_title：FEBS letters

authors： Marijan D,Tse R,Elliott K,Chandhok S,Luo M,Lacroix E,Audas TE

更新日期：2019-11-01 00:00:00

abstract：:The cardiac and skeletal muscle isoforms of calsequestrin (CS), the low affinity, high capacity Ca2+ binding protein localized in the lumen of sarcoplasmic reticulum, are the products of two different genes (Fliegel, L., Leberer, E., Green, N.M. and MacLennan, D.H. (1982) FEBS Lett. 242, 297-300), and can be both puri...

journal_title：FEBS letters

authors： Biral D,Volpe P,Damiani E,Margreth A

更新日期：1992-03-09 00:00:00

abstract：:We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containi...

journal_title：FEBS letters

authors： Sano S,Ohnishi H,Omori A,Hasegawa J,Kubota M

更新日期：1997-07-14 00:00:00

abstract：:Polyamine depletion, obtained in FAO cells with specific inhibitors of biosynthetic enzymes, prevents or decreases the accumulation of hsp 70 mRNA following heat shock [Desiderio et al., Hepatology 24 (1996) 150-156]. The present study shows that under conditions of spermidine depletion caused by alpha-difluoromethylo...

journal_title：FEBS letters

authors： Desiderio MA,Dansi P,Tacchini L,Bernelli-Zazzera A

更新日期：1999-07-16 00:00:00

abstract：:cAMP levels in Paramecium increased dose dependently after a step increase of [Ca] or [Sr] in the incubation, provided K was present. Two mM Ca or Sr tripled cAMP concentrations within 3 s and induced an increase in forward swimming speed. The increase in cAMP formation was strictly dependent on the Donnan ratio [K]: ...

journal_title：FEBS letters

authors： Schultz JE,Grünemund R,von Hirschhausen R,Schönefeld U

更新日期：1984-02-13 00:00:00

abstract：:Bromodomains present in Brd4 and other chromatin proteins interact with acetylated histones to regulate transcription and cell growth. To study Brd4-chromatin interactions in vivo, histone H4 tail peptides were fused to a synthetic protein transduction domain (PTD) derived from the human immunodeficiency virus Tat and...

journal_title：FEBS letters

authors： Nishiyama A,Mochizuki K,Mueller F,Karpova T,McNally JG,Ozato K

更新日期：2008-04-30 00:00:00

abstract：:The dual function of the regulatory beta-subunit of protein kinase CK2 is highlighted by its ability to abolish calmodulin phosphorylation in contrast to its stimulatory effect on the phosphorylation of peptide substrates. Here we show that a synthetic peptide reproducing the C-terminal region of the beta-subunit (bet...

journal_title：FEBS letters

authors： Marin O,Meggio F,Boldyreff B,Issinger OG,Pinna LA

更新日期：1995-04-17 00:00:00