Abstract:
:LncRNAs have a critical role in the regulation of cellular processes such as cancer progression and metastasis. In the present study, we confirmed that TUG1 was overexpressed in bladder cancer tissues and established cell lines. Knockdown of TUG1 inhibited bladder cancer cell metastasis both in vitro and in vivo. Furthermore, we found that TUG1 promoted cancer cell invasion and radioresistance through inducing epithelial-to-mesenchymal transition (EMT). Interestingly, TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner. ZEB2 was identified as a down-stream target of miR-145 and TUG1 exerted its function through the miR-145/ZEB2 axis. In summary, our data indicated that blocking TUG1 function may be an effective anti-cancer therapy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tan J,Qiu K,Li M,Liang Ydoi
10.1016/j.febslet.2015.08.020subject
Has Abstractpub_date
2015-10-07 00:00:00pages
3175-81issue
20 Pt Beissn
0014-5793issn
1873-3468pii
S0014-5793(15)00720-6journal_volume
589pub_type
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