Abstract:
:Calpain, a Ca2+-dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure-function relationship of calpain and X-ray analysis of its Ca2+-binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Suzuki K,Sorimachi Hdoi
10.1016/s0014-5793(98)00856-4subject
Has Abstractpub_date
1998-08-14 00:00:00pages
1-4issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00856-4journal_volume
433pub_type
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