Abstract:
:Tertiary structure models of Interleukin-6 were constructed using a routine prediction method based on the X-ray crystal structures of granulocyte colony-stimulating factor (GCSF) and leukemia inhibitory factor (LIF). The models were evaluated with the aid of the sequence-structure compatibility (3D-1D) method program compass and NMR experimental information. The model constructed from GCSF gained higher scores on compass examination than did that from LIF, and the NOE data [Nishimura et al. (1996) Biochemistry 35, 273-281] also turned to be more consistent with the former model.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sumikawa H,Fukuhara K,Suzuki E,Matsuo Y,Nishikawa Kdoi
10.1016/s0014-5793(97)00115-4subject
Has Abstractpub_date
1997-03-10 00:00:00pages
234-40issue
2-3eissn
0014-5793issn
1873-3468pii
S0014579397001154journal_volume
404pub_type
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